PMID- 12703549
OWN - NLM
STAT- MEDLINE
DCOM- 20031119
LR  - 20191025
IS  - 0914-9465 (Print)
IS  - 0914-9465 (Linking)
VI  - 66
IP  - 1
DP  - 2003 Mar
TI  - Germ cell apoptosis and its molecular trigger in mouse testes.
PG  - 1-16
AB  - Germ cell apoptosis is very common during various stages of mammalian testicular 
      development. However, our understanding of the mechanisms underlying male germ 
      cell apoptosis is still limited. This review firstly covers the general features 
      of germ cell death in normal testes of fetal, neonatal, and adult mice from 
      electron microscopy (EM) and terminal dUTP nick-end labeling (TUNEL) staining. 
      The issue of whether the Fas and Fas ligand (FasL) system and/or the Bax and 
      Bcl-2 system is involved in the induction of germ cell apoptosis in normal and 
      damaged testes will then be addressed, including a special consideration of the 
      ischemia-reperfusion model, the endocrine disruptor-treated model, and others. 
      Finally, this review will propose that the process of normal spermatogenesis 
      seems skillfull in taking advantage of apoptotic processes of germ cells and that 
      different molecular pathways may be triggered to induce male germ cell apoptosis, 
      depending upon the physiological and pathological states of germ cells.
FAU - Koji, Takehiko
AU  - Koji T
AD  - Department of Histology and Cell Biology, Nagasaki University School of Medicine, 
      Nagasaki, Japan. tkoji@net.nagasaki-u.ac.jp
FAU - Hishikawa, Yoshitaka
AU  - Hishikawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Arch Histol Cytol
JT  - Archives of histology and cytology
JID - 8806082
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Male
MH  - Mice
MH  - Spermatids/*cytology
MH  - Testis/*cytology/*embryology/physiology
EDAT- 2003/04/22 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/04/22 05:00
PHST- 2003/04/22 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/04/22 05:00 [entrez]
AID - 10.1679/aohc.66.1 [doi]
PST - ppublish
SO  - Arch Histol Cytol. 2003 Mar;66(1):1-16. doi: 10.1679/aohc.66.1.