PMID- 12703556
OWN - NLM
STAT- MEDLINE
DCOM- 20031119
LR  - 20191025
IS  - 0914-9465 (Print)
IS  - 0914-9465 (Linking)
VI  - 66
IP  - 1
DP  - 2003 Mar
TI  - The periodontal Ruffini endings in brain derived neurotrophic factor (BDNF) 
      deficient mice.
PG  - 73-81
AB  - Innervation and terminal morphology in the lingual periodontal ligament of the 
      incisor were investigated in brain derived neurotrophic factor (BDNF) 
      heterozygous mice and littermate wild-type mice (aged two months) using 
      immunohistochemistry for protein gene product 9.5 (PGP 9.5), a general neuronal 
      marker. In addition, computer-assisted quantitative analysis was performed for a 
      comparison of neuronal density in the periodontal ligament between heterozygous 
      and wild-type mice. In wild-type mice, the periodontal ligament was found to be 
      richly innervated by the mechanoreceptive Ruffini endings and nociceptive free 
      nerve endings in the alveolus-related part of the periodontal ligament. The 
      periodontal Ruffini endings in the wild-type mice incisor ligament were 
      classified into two types: type I with ruffled outlines, and type II with a 
      smooth outline. BDNF heterozygous mice showed malformations of the type I Ruffini 
      endings which included fewer nerve fibers and fewer ramifications than those in 
      wild-type mice as well as smooth outlines of the axon terminals. Quantitative 
      analysis under a confocal microscope showed a roughly 18% reduction in neuronal 
      density in the periodontal ligament of the heterozygous mice. These findings 
      suggest that the development and maturation of the periodontal Ruffini endings 
      require BDNF.
FAU - Alkhamrah, Bashar Anas
AU  - Alkhamrah BA
AD  - Divisions of Oral Anatomy, Department of Oral Biological Science, Niigata 
      University Graduate School of Medical and Dental Sciences, Gakkocho-dori, 
      Niigata, Japan.
FAU - Hoshino, Natalia
AU  - Hoshino N
FAU - Kawano, Yoshiro
AU  - Kawano Y
FAU - Harada, Fumiko
AU  - Harada F
FAU - Hanada, Kooji
AU  - Hanada K
FAU - Maeda, Takeyasu
AU  - Maeda T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Arch Histol Cytol
JT  - Archives of histology and cytology
JID - 8806082
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Gene Expression Regulation, Developmental
MH  - Genotype
MH  - Heterozygote
MH  - Incisor/growth & development/innervation
MH  - Mechanoreceptors/*cytology/*growth & development
MH  - Mice
MH  - Mice, Knockout
MH  - Periodontal Ligament/*growth & development/*innervation
EDAT- 2003/04/22 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/04/22 05:00
PHST- 2003/04/22 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/04/22 05:00 [entrez]
AID - 10.1679/aohc.66.73 [doi]
PST - ppublish
SO  - Arch Histol Cytol. 2003 Mar;66(1):73-81. doi: 10.1679/aohc.66.73.