PMID- 12703883
OWN - NLM
STAT- MEDLINE
DCOM- 20030804
LR  - 20191025
IS  - 0391-3988 (Print)
IS  - 0391-3988 (Linking)
VI  - 26
IP  - 3
DP  - 2003 Mar
TI  - An association between aortic pulse wave velocity, blood pressure and chronic 
      inflammation in ESRD patients on peritoneal dialysis.
PG  - 188-95
AB  - Increased aortic pulse wave velocity (AoPWV) has been identified as a risk factor 
      for cardiovascular morbidity in the general population and in patients on 
      dialysis. Most of the studies in ESRD patients refer to subjects on hemodialysis. 
      Influence of the inflammatory process on aortic stiffening remains largely 
      unknown. The aim of the present study was to evaluate potential relationships 
      between AoPWV and blood pressure, basic anthropometric parameters, selected 
      growth factors and markers of the inflammatory process in ESRD patients treated 
      with peritoneal dialysis. The study population consisted of 43 patients (19 F, 24 
      M) with a mean age of 50.6 +/- 13.4 years on PD for a mean period of 21.9 +/- 
      20.7 months. AoPWV was measured using two pressure transducers placed on the 
      carotid and femoral arteries and connected to an automatic processor (Complion 
      Colson AS, Paris, France). Serum levels of Tumor Necrosis Factor alpha 
      (TNFalpha), interleukin 6 (IL-6) and plasma basic Fibroblast Growth Factor (bFGF) 
      were measured with ELISA; C-reactive protein and fibrinogen with nephelometry. 
      Serum lipid profile was also assessed. Blood pressure was measured in an 
      outpatient department under standardized conditions. Mean aortic pulse wave 
      velocity in the study population was 10.7 +/- 2.1 m/s. No difference in AoPWV was 
      found between men and women. AoPWV correlated significantly with age (R = 0.41; p 
      < 0.01) but not with time on dialysis. Positive relationship between AoPWV and 
      body weight and BMI was shown (R = 0.31; p < 0.05 and R = 0.35; p < 0.05, 
      respectively). AoPWV correlated significantly with systolic blood pressure (SBP), 
      mean arterial pressure (MAP) and pulse pressure (PP) (R = 0.46, p < 0.005, R = 
      0.46, p < 0.005 and R = 0.43, p < 0.01, respectively). AoPWV correlated with 
      serum IL-6 and plasma bFGF (R = 0.32, p < 0.05 and R = 0.4, p < 0.01; 
      respectively). The correlation with serum CRP was borderline significant (p < 
      0.53). In multiple regression analysis age (beta 0.38; p < 0.005), plasma bFGF 
      level (beta 0.3; p < 0.05), and systolic blood pressure (beta 0.29; p < 0.05) 
      were independently associated with pulse wave velocity. Our results suggest that 
      AoPWV values in patients on PD are associated with factors similar to those 
      encountered in the general population. We suggest that increased aortic 
      stiffening may also be related to the chronic inflammatory process in PD 
      patients.
FAU - Stompor, T
AU  - Stompor T
AD  - Department of Nephrology, Jagiellonian University, Cracow, Poland. stompin@mp.pl
FAU - Rajzer, M
AU  - Rajzer M
FAU - Sulowicz, W
AU  - Sulowicz W
FAU - Dembinska-Kiec, A
AU  - Dembinska-Kiec A
FAU - Janda, K
AU  - Janda K
FAU - Kawecka-Jaszcz, K
AU  - Kawecka-Jaszcz K
FAU - Wojcik, K
AU  - Wojcik K
FAU - Tabor, B
AU  - Tabor B
FAU - Zdzienicka, A
AU  - Zdzienicka A
FAU - Janusz-Grzybowska, E
AU  - Janusz-Grzybowska E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Artif Organs
JT  - The International journal of artificial organs
JID - 7802649
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Growth Substances)
SB  - IM
MH  - Acute-Phase Proteins/analysis
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anthropometry
MH  - Aorta/*physiology/physiopathology
MH  - Biomarkers/blood
MH  - Blood Pressure/*physiology
MH  - Chronic Disease
MH  - Cytokines/blood
MH  - Female
MH  - Growth Substances/blood
MH  - Humans
MH  - Inflammation/*physiopathology
MH  - Kidney Failure, Chronic/*immunology/physiopathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Peritoneal Dialysis/*methods
MH  - Pulsatile Flow/*physiology
EDAT- 2003/04/22 05:00
MHDA- 2003/08/05 05:00
CRDT- 2003/04/22 05:00
PHST- 2003/04/22 05:00 [pubmed]
PHST- 2003/08/05 05:00 [medline]
PHST- 2003/04/22 05:00 [entrez]
AID - 10.1177/039139880302600302 [doi]
PST - ppublish
SO  - Int J Artif Organs. 2003 Mar;26(3):188-95. doi: 10.1177/039139880302600302.