PMID- 12704117
OWN - NLM
STAT- MEDLINE
DCOM- 20030515
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 71
IP  - 5
DP  - 2003 May
TI  - Mice genetically deficient in immunoglobulin E are more permissive hosts than 
      wild-type mice to a primary, but not secondary, infection with the filarial 
      nematode Brugia malayi.
PG  - 2462-7
AB  - Primary and secondary murine and human infections with Brugia malayi are 
      characterized by substantial increases in levels of immunoglobulin E (IgE). To 
      investigate whether this is necessary for worm clearance, IgE(-/-) mice were 
      subjected to primary- and secondary-infection protocols. Following a primary 
      infection, IgE(-/-) mice displayed a profound deficit in their ability to clear 
      an intraperitoneal injection of L3 infective-stage larvae in comparison to 
      wild-type counterparts and maintained substantial worm burdens as late as 10 
      weeks postinfection. Although viable adult parasites were recovered at this late 
      time point from IgE(-/-) mice, the majority of the mice remained free of 
      microfilariae. IgE(-/-) cohorts subjected to a secondary-infection protocol were 
      able to clear the challenge inoculation in an accelerated manner, with kinetics 
      similar to that observed in the wild-type animals. Analysis of the humoral 
      response in IgE(-/-) mice following infection demonstrates a defect in IgG1 and 
      IgG2a production, in addition to the expected lack of IgE. The IgG1 deficiency is 
      no longer evident following a secondary infection. These data imply that 
      deficiencies other than IgE production (i.e., IgG1 production) deficiency may be 
      responsible for the increased permissiveness of IgE(-/-) mice as hosts following 
      infection with B. malayi.
FAU - Spencer, L A
AU  - Spencer LA
AD  - Department of Pathology, University of Connecticut Health Center, Farmington, 
      Connecticut 06030-3105, USA.
FAU - Porte, P
AU  - Porte P
FAU - Zetoff, C
AU  - Zetoff C
FAU - Rajan, T V
AU  - Rajan TV
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - *Brugia malayi
MH  - Filariasis/*immunology
MH  - Immunoglobulin E/*deficiency
MH  - Immunoglobulin G/biosynthesis/classification
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Parasitemia/immunology
MH  - Peritoneal Cavity/cytology
PMC - PMC153289
EDAT- 2003/04/22 05:00
MHDA- 2003/05/16 05:00
PMCR- 2003/05/01
CRDT- 2003/04/22 05:00
PHST- 2003/04/22 05:00 [pubmed]
PHST- 2003/05/16 05:00 [medline]
PHST- 2003/04/22 05:00 [entrez]
PHST- 2003/05/01 00:00 [pmc-release]
AID - 1748 [pii]
AID - 10.1128/IAI.71.5.2462-2467.2003 [doi]
PST - ppublish
SO  - Infect Immun. 2003 May;71(5):2462-7. doi: 10.1128/IAI.71.5.2462-2467.2003.