PMID- 12706466
OWN - NLM
STAT- MEDLINE
DCOM- 20031202
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 467
IP  - 1-3
DP  - 2003 Apr 25
TI  - Fever induced by platelet-derived growth factor, in contrast to fever induced by 
      lipopolysaccharide, depends only on nitric oxide, but not on carbon monoxide 
      pathway.
PG  - 133-40
AB  - Platelet-derived growth factor (PDGF) is a multifunctional protein which is known 
      to induce a febrile response when injected intracerebroventricularly. The gaseous 
      neurotransmitters, nitric oxide (NO) and carbon monoxide (CO), are both known to 
      exert thermoregulatory effects and to participate in lipopolysaccharide-induced 
      fever. In this study, we investigated the role of NO and CO in the febrile 
      response to PDGF-BB in rats. Intracerebroventricular (i.c.v.) injection of 
      PDGF-BB produced a dose-dependent increase in body temperature. This increase in 
      body temperature induced by PDGF-BB was exacerbated by N(G)-nitro-L-arginine 
      methyl ester (L-NAME-a nonselective NO synthase inhibitor) and 
      S-methyl-L-thiocitrulline treatment [SMTC-a neuronal NOS (nNOS) selective 
      inhibitor], but not by aminoguanidine treatment [an inducible NOS (iNOS) 
      selective inhibitor]. Zinc deuteroporphyrin 2,4-bis glycol treatment (ZnDPBG-a 
      nonselective heme oxygenase (HO) blocker) did not affect PDGF-BB fever. Our data 
      indicate that the NO but not the CO pathway participates in PDGF-BB fever. 
      Furthermore, our data show that nNOS is the NOS isoform responsible for NO 
      synthesis in this response.
FAU - Almeida, Maria Camila
AU  - Almeida MC
AD  - Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Universidade 
      de Sao Paulo, 14049-900, Ribeirao Preto, SP, Brazil.
FAU - Pela, Irene Rosemir
AU  - Pela IR
FAU - Branco, Luiz Guilherme S
AU  - Branco LG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Deuteroporphyrins)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Isoenzymes)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Proto-Oncogene Proteins c-sis)
RN  - 119700-81-1 (zinc deuteroporphyrin IX 2,4-bis(glycol))
RN  - 1B56C968OA (Becaplermin)
RN  - 29VT07BGDA (Citrulline)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 7U1EE4V452 (Carbon Monoxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.13.39 (Nos2 protein, rat)
RN  - EC 1.14.14.18 (Heme Oxygenase (Decyclizing))
RN  - GYV9AM2QAG (Thiourea)
RN  - M790X706JV (S-methylthiocitrulline)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Becaplermin
MH  - Body Temperature/drug effects/physiology
MH  - Carbon Monoxide/*physiology
MH  - Citrulline/*analogs & derivatives/pharmacology
MH  - Deuteroporphyrins/pharmacology
MH  - Enzyme Inhibitors/pharmacology
MH  - Fever/chemically induced/*metabolism
MH  - Heme Oxygenase (Decyclizing)/antagonists & inhibitors/physiology
MH  - Isoenzymes/antagonists & inhibitors
MH  - *Lipopolysaccharides
MH  - Male
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Nitric Oxide/*physiology
MH  - Nitric Oxide Synthase/antagonists & inhibitors/physiology
MH  - Nitric Oxide Synthase Type II
MH  - Platelet-Derived Growth Factor/antagonists & inhibitors/*physiology
MH  - Proto-Oncogene Proteins c-sis
MH  - Rats
MH  - Rats, Wistar
MH  - Thiourea/*analogs & derivatives/pharmacology
EDAT- 2003/04/23 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/04/23 05:00
PHST- 2003/04/23 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/04/23 05:00 [entrez]
AID - S0014299903016364 [pii]
AID - 10.1016/s0014-2999(03)01636-4 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2003 Apr 25;467(1-3):133-40. doi: 10.1016/s0014-2999(03)01636-4.