PMID- 12707370
OWN - NLM
STAT- MEDLINE
DCOM- 20031212
LR  - 20181113
IS  - 1525-1578 (Print)
IS  - 1525-1578 (Linking)
VI  - 5
IP  - 2
DP  - 2003 May
TI  - Clinical applications of BCR-ABL molecular testing in acute leukemia.
PG  - 63-72
AB  - Recent advances in molecular genetics impact the health care and outcome of 
      patients with acute lymphoblastic leukemia (ALL). BCR-ABL, a common molecular 
      defect in adult ALL, is a valuable tumor marker whose detection influences 
      prognosis and clinical management decisions. Molecular methods such as 
      fluorescence in situ hybridization (FISH), reverse-transcriptase polymerase chain 
      reaction (rtPCR), and real-time quantitative rtPCR can be used to detect the 
      chimeric BCR-ABL gene or its transcripts. These molecular assays improve our 
      ability to measure residual disease and to estimate risk of relapse. On the 
      horizon are gene expression profiles that will likely provide additional 
      information beyond what is obtainable with current clinical and laboratory 
      approaches.
FAU - Nashed, Amgad L
AU  - Nashed AL
AD  - Department of Pathology and Laboratory Medicine, University of North Carolina at 
      Chapel Hill, Chapel Hill, North Carolina 27599-7525, USA.
FAU - Rao, Kathleen W
AU  - Rao KW
FAU - Gulley, Margaret L
AU  - Gulley ML
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Mol Diagn
JT  - The Journal of molecular diagnostics : JMD
JID - 100893612
RN  - 0 (Benzamides)
RN  - 0 (Piperazines)
RN  - 0 (Pyrimidines)
RN  - 0 (RNA, Messenger)
RN  - 8A1O1M485B (Imatinib Mesylate)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - Benzamides
MH  - Blotting, Southern
MH  - Chromosomes, Human, Pair 22/ultrastructure
MH  - Chromosomes, Human, Pair 9/ultrastructure
MH  - Fusion Proteins, bcr-abl/*analysis
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Imatinib Mesylate
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Karyotyping
MH  - Models, Genetic
MH  - Oligonucleotide Array Sequence Analysis/*methods
MH  - Piperazines/therapeutic use
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/*genetics
MH  - Prognosis
MH  - Pyrimidines/therapeutic use
MH  - RNA, Messenger/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Time Factors
PMC - PMC1907317
EDAT- 2003/04/23 05:00
MHDA- 2003/12/13 05:00
PMCR- 2004/05/01
CRDT- 2003/04/23 05:00
PHST- 2003/04/23 05:00 [pubmed]
PHST- 2003/12/13 05:00 [medline]
PHST- 2003/04/23 05:00 [entrez]
PHST- 2004/05/01 00:00 [pmc-release]
AID - S1525-1578(10)60454-0 [pii]
AID - 0122 [pii]
AID - 10.1016/S1525-1578(10)60454-0 [doi]
PST - ppublish
SO  - J Mol Diagn. 2003 May;5(2):63-72. doi: 10.1016/S1525-1578(10)60454-0.