PMID- 12708525
OWN - NLM
STAT- MEDLINE
DCOM- 20030604
LR  - 20190910
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 117
IP  - 2
DP  - 2003 Apr
TI  - Ontogeny of eyeblink conditioned response timing in rats.
PG  - 283-91
AB  - Eyeblink conditioned response (CR) timing was assessed in adult and infant rats. 
      In Experiment 1, adult rats were trained with a 150-ms tone conditioned stimulus 
      (CS) paired with a periorbital shock unconditioned stimulus (US; presented at 
      200- or 500-ms interstimulus intervals [ISIs]). The rats acquired CRs with 2 
      distinct peaks that occurred just before the US onset times. Experiments 2 and 3 
      examined developmental changes in CR timing in pups trained on Postnatal Days 
      24-26 or 32-34. Experiment 3 used a delay conditioning procedure in which the 
      tone CS continued throughout the ISIs. Pups of both ages exhibited robust 
      conditioning. However, there were age-related increases in the percentage of 
      double-peaked CRs and in CR timing precision. Ontogenetic changes in eyeblink CR 
      timing may be related to developmental changes in cerebellar cortical or 
      hippocampal function.
FAU - Freeman, John H Jr
AU  - Freeman JH Jr
AD  - Department of Psychology, University of Iowa, Iowa City 52242, USA. 
      john-freeman@uiowa.edu
FAU - Nicholson, Daniel A
AU  - Nicholson DA
FAU - Muckler, Adam S
AU  - Muckler AS
FAU - Rabinak, Christine A
AU  - Rabinak CA
FAU - DiPietro, Norma T
AU  - DiPietro NT
LA  - eng
GR  - NS38890/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal/physiology
MH  - Conditioning, Classical/physiology
MH  - Conditioning, Eyelid/*physiology
MH  - Extinction, Psychological
MH  - Learning
MH  - Male
MH  - Memory, Short-Term
MH  - Ocular Physiological Phenomena
MH  - Rats
MH  - Rats, Long-Evans
MH  - Reaction Time/physiology
EDAT- 2003/04/24 05:00
MHDA- 2003/06/05 05:00
CRDT- 2003/04/24 05:00
PHST- 2003/04/24 05:00 [pubmed]
PHST- 2003/06/05 05:00 [medline]
PHST- 2003/04/24 05:00 [entrez]
AID - 10.1037/0735-7044.117.2.283 [doi]
PST - ppublish
SO  - Behav Neurosci. 2003 Apr;117(2):283-91. doi: 10.1037/0735-7044.117.2.283.