PMID- 12708822
OWN - NLM
STAT- MEDLINE
DCOM- 20030515
LR  - 20071115
IS  - 0137-1320 (Print)
IS  - 0137-1320 (Linking)
VI  - 51
IP  - 4
DP  - 2002
TI  - Patients with unstable angina pectoris present increased humoral response against 
      Helicobacter pylori in comparison with patients with aggravated dyspepsia.
PG  - 339-44
AB  - A role of autoimmune process and its link with bacterial infections in initiation 
      or aggravation of atherosclerosis symptoms has been suggested. Antigenic mimicry 
      and cross-reactivity of circulating antibodies have been indicated as some major 
      factors in this process. In this study, the prevalence and titers of IgG and IgA 
      antibodies reacting with glycine extract of H. pylori surface antigens were 
      determined immunoenzymatically (ELISA) in the group of patients with unstable 
      ischaemic heart disease and in patients with aggravated dyspepsia. Our results 
      reveal that elevated titers of IgG anti-H. pylori are more typical for cardiac 
      patients and lower prevalence of IgA anti-H. pylori--for those with aggravated 
      dyspepsia. This supports the hypothesis that intensed humoral response in 
      immunoglobulins class G against some bacterial antigens may play a role in the 
      aggravation of symptoms of coronary atherosclerosis.
FAU - Rechcinski, Tomasz
AU  - Rechcinski T
AD  - Department of Cardiology IMW, Medical University, ul. Kniaziewicza 1/5, 91-347 
      Lodz, Poland.
FAU - Kasprzak, Jaroslaw D
AU  - Kasprzak JD
FAU - Chmiela, Magdalena
AU  - Chmiela M
FAU - Krzeminska-Pakula, Maria
AU  - Krzeminska-Pakula M
FAU - Rudnicka, Wieslawa
AU  - Rudnicka W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Acta Microbiol Pol
JT  - Acta microbiologica Polonica
JID - 7610362
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Angina, Unstable/*immunology/microbiology
MH  - Antibodies, Bacterial/*blood
MH  - Coronary Artery Disease/etiology
MH  - Dyspepsia/*immunology/microbiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Helicobacter pylori/*immunology
MH  - Humans
MH  - Immunoglobulin A/blood
MH  - Immunoglobulin G/blood
MH  - Male
MH  - Middle Aged
EDAT- 2003/04/24 05:00
MHDA- 2003/05/16 05:00
CRDT- 2003/04/24 05:00
PHST- 2003/04/24 05:00 [pubmed]
PHST- 2003/05/16 05:00 [medline]
PHST- 2003/04/24 05:00 [entrez]
PST - ppublish
SO  - Acta Microbiol Pol. 2002;51(4):339-44.