PMID- 12708976
OWN - NLM
STAT- MEDLINE
DCOM- 20030902
LR  - 20190823
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 58
IP  - 4
DP  - 2003 Apr
TI  - Prospective study of mustard allergy: first study with double-blind 
      placebo-controlled food challenge trials (24 cases).
PG  - 295-9
AB  - BACKGROUND: Mustard allergy accounts for 1.1% of food allergies in children. 
      However, double-blind placebo-controlled food challenge trials (DB PCFCs) have 
      not yet been proposed. OBJECTIVE: To carry out DB PCFCs to determine the real 
      frequency of mustard allergy in patients sensitized to mustard. METHODS: A 
      prospective study was conducted in 30 subjects aged 3-20 years presenting 
      positive prick tests to ground mustard seeds (Brassica nigra), mustard flour (B. 
      juncea), metabisulfite-free strong mustard seasoning (B. juncea) and a 
      commercialized allergenic extract (B. nigra). Twenty-seven subjects were screened 
      for mustard-specific immunoglobulin E (IgE). PCFCs were carried out either DB or 
      single blind (SB) with up to 1340 mg of metabisulfite-free seasoning. RESULTS: 
      The mean diameter of the wheal induced by prick tests with the allergenic extract 
      was lower (n.s.) than that induced by the native mustard products: 5.8 mm 
      (1.5-15) vs 6.9 mm (0.5-18) for B. nigra ground seeds, 7.8 mm (1-20) for B. 
      juncea flour and 9.7 mm (3-20) for the strong mustard seasoning. The diameter of 
      the wheal induced by the allergenic extract was significantly different from that 
      induced by the mustard seasoning (P < 0.005). The mean of mustard specific-IgE 
      values was 8.7 KU/l (0.35-72.4). Seven of 30 food challenges were considered 
      positive. Mean prick test results in the positive and negative PCFC subgroups 
      were 5.5 mm vs 5.9 mm for the commercialized extract, 10.9 mm vs 5.8 mm for B. 
      nigra ground seeds (P < 0.01), 9.9 mm vs 7.1 mm for B. juncea flour (n.s. P > 
      0.25) and 11.5 mm vs 9.1 mm for the metabisulfite-free mustard seasoning (n.s. P 
      > 0.1). Mean specific IgE values determined by CAP system radioallergosorbent 
      test (Phadebas Pharmacia) were higher but not significantly so (P > 0.25) in the 
      subgroup with mustard allergy (12.3 K/l vs 7.6 KU/l). CONCLUSIONS: About 23.3% of 
      the sensitized subjects were allergic to a routine dose of mustard. Positive 
      prick tests and the presence of specific IgE were not predictive. SB PCFC or DB 
      PCFC is required before recommending avoidance diets.
FAU - Morisset, M
AU  - Morisset M
AD  - Department of Internal Medicine, Clinical Immunology and Allergology, Nancy, 
      France.
FAU - Moneret-Vautrin, D-A
AU  - Moneret-Vautrin DA
FAU - Maadi, F
AU  - Maadi F
FAU - Fremont, S
AU  - Fremont S
FAU - Guenard, L
AU  - Guenard L
FAU - Croizier, A
AU  - Croizier A
FAU - Kanny, G
AU  - Kanny G
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Allergy. 2003 Apr;58(4):287-8. PMID: 12708974
MH  - Abdominal Pain/etiology
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Conjunctivitis/etiology
MH  - Dermatitis, Allergic Contact/etiology
MH  - Diarrhea/etiology
MH  - Double-Blind Method
MH  - Female
MH  - Flour
MH  - Food Hypersensitivity/*complications/diagnosis/*etiology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Mustard Plant/*adverse effects
MH  - Prospective Studies
MH  - Respiratory Sounds
MH  - Rhinitis/etiology
MH  - Seeds
MH  - Single-Blind Method
MH  - Skin Tests
MH  - Sneezing
EDAT- 2003/04/24 05:00
MHDA- 2003/09/03 05:00
CRDT- 2003/04/24 05:00
PHST- 2003/04/24 05:00 [pubmed]
PHST- 2003/09/03 05:00 [medline]
PHST- 2003/04/24 05:00 [entrez]
AID - 074 [pii]
AID - 10.1034/j.1398-9995.2003.00074.x [doi]
PST - ppublish
SO  - Allergy. 2003 Apr;58(4):295-9. doi: 10.1034/j.1398-9995.2003.00074.x.