PMID- 12709305
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230320
IS  - 1476-3524 (Electronic)
IS  - 1029-8428 (Linking)
VI  - 4
IP  - 7-8
DP  - 2002 Nov-Dec
TI  - Brain-derived neurotrophic factor controls dopamine D3 receptor expression: 
      implications for neurodevelopmental psychiatric disorders.
PG  - 671-678
AB  - Brain-derived neurotrophic factor (BDNF) belongs to a family of proteins related 
      to nerve growth factor, which are responsible for neuron proliferation, survival 
      and differentiation. A more diverse role for BDNF as a neuronal extracellular 
      transmitter has, nevertheless, been proposed. The dopamine D(3) receptor has been 
      implicated in neuropsychiatric disorders including schizophrenia, drug addiction, 
      depression and Parkinson's disease. Its expression during development and in 
      adulthood is highly dependent on dopaminergic innervation. Here we show that BDNF 
      synthesized by dopamine neurons is responsible for the appearance of the D(3) 
      receptor during development and maintains D(3) receptor expression in adults. 
      Moreover, BDNF triggers D(3) receptor overexpression and behavioral sensitization 
      to levodopa in denervated animals. These results suggest that BDNF, by 
      controlling the expression of specific genes such as the D(3) receptor gene, may 
      be an important factor in neurodevelopmental psychiatric diseases.
FAU - Sokoloff, Pierre
AU  - Sokoloff P
AD  - Unite de Neurobiologie et Pharmacologie Moleculaire, INSERM U 573, Centre Paul 
      Broca, 2ter rue d' Alesia, 75014 Paris, France.
FAU - Guillin, Olivier
AU  - Guillin O
FAU - Diaz, Jorge
AU  - Diaz J
FAU - Carroll, Patrick
AU  - Carroll P
FAU - Griffon, Nathalie
AU  - Griffon N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurotox Res
JT  - Neurotoxicity research
JID - 100929017
EDAT- 2003/04/24 05:00
MHDA- 2003/04/24 05:01
CRDT- 2003/04/24 05:00
PHST- 2003/04/24 05:00 [pubmed]
PHST- 2003/04/24 05:01 [medline]
PHST- 2003/04/24 05:00 [entrez]
AID - 10.1080/1029842021000045499 [doi]
PST - ppublish
SO  - Neurotox Res. 2002 Nov-Dec;4(7-8):671-678. doi: 10.1080/1029842021000045499.