PMID- 12713097
OWN - NLM
STAT- MEDLINE
DCOM- 20031204
LR  - 20190922
IS  - 0920-5063 (Print)
IS  - 0920-5063 (Linking)
VI  - 14
IP  - 3
DP  - 2003
TI  - Acid-initiated polymerization of epsilon-caprolactone under microwave irradiation 
      and its application in the preparation of drug controlled release system.
PG  - 241-53
AB  - Acid-initiated ring-opening polymerization (ROP) of epsilon-caprolactone 
      (epsilon-CL) was conducted under microwave irradiation (MI) at 2.45 GHz. At this 
      frequency, metallic catalysts were no longer necessary. The effects of microwave 
      power, irradiation time, epsilon-CL: acid molar ratio and acidity of acid on the 
      polymerization were investigated. Both the rate of polymerization and the molar 
      mass of polymer obtained were enhanced in comparison with conventional thermal 
      method. Poly(epsilon-caprolactone) (PCL) with weight-average molar mass (Mw) over 
      12000 g/mol and Mw/Mn below 1.6 was synthesized in the presence of carboxylic 
      acids such as maleic acid (MA), succinic acid (SA) and adipic acid (AA). The 
      polymerization was also carried out when the monomer contained a certain amount 
      of ibuprofen (IBU), by which, the IBU-PCL controlled release system was prepared 
      directly. The release of IBU from the system was sustained from 12 h to 9 days 
      with IBU content in weight increasing from 5 to 20%. It seems that this is a 
      promising method to prepare drug controlled release systems.
FAU - Song, Ying
AU  - Song Y
AD  - Department of Polymer Science, College of Chemistry and Molecular Science, Wuhan 
      University, Wuhan 430072, P. R. China.
FAU - Liu, Lijian
AU  - Liu L
FAU - Weng, Xiaocheng
AU  - Weng X
FAU - Zhuo, Renxi
AU  - Zhuo R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Biomater Sci Polym Ed
JT  - Journal of biomaterials science. Polymer edition
JID - 9007393
RN  - 0 (Biocompatible Materials)
RN  - 0 (Caproates)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Lactones)
RN  - 56RE988L1R (caprolactone)
SB  - IM
MH  - Biocompatible Materials
MH  - Caproates/*chemistry/*radiation effects
MH  - *Delayed-Action Preparations
MH  - Lactones/*chemistry/*radiation effects
MH  - Magnetic Resonance Spectroscopy
MH  - *Microwaves
MH  - Molecular Structure
MH  - Spectroscopy, Fourier Transform Infrared
EDAT- 2003/04/26 05:00
MHDA- 2003/12/05 05:00
CRDT- 2003/04/26 05:00
PHST- 2003/04/26 05:00 [pubmed]
PHST- 2003/12/05 05:00 [medline]
PHST- 2003/04/26 05:00 [entrez]
AID - 10.1163/156856203763572699 [doi]
PST - ppublish
SO  - J Biomater Sci Polym Ed. 2003;14(3):241-53. doi: 10.1163/156856203763572699.