PMID- 12714042
OWN - NLM
STAT- MEDLINE
DCOM- 20040202
LR  - 20191107
IS  - 0945-053X (Print)
IS  - 0945-053X (Linking)
VI  - 22
IP  - 1
DP  - 2003 Mar
TI  - Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis.
PG  - 55-61
AB  - The matrix metalloproteinases (MMPs) constitute a multigene family of over 23 
      secreted and cell-surface associated enzymes that cleave or degrade various 
      pericellular substrates. In addition to virtually all extracellular matrix (ECM) 
      compounds, their targets include other proteinases, chemotactic molecules, latent 
      growth factors, growth factor-binding proteins and cell surface molecules. The 
      MMP activity is controlled by the physiological tissue inhibitors of MMPs 
      (TIMPs). There is much evidence that MMPs and their inhibitors play a key role 
      during extracellular remodeling in physiological situations and in cancer 
      progression. They have other functions that promoting tumor invasion. Indeed, 
      they regulate early stages of tumor progression such as tumor growth and 
      angiogenesis. Membrane type MMPs (MT-MMPs) constitute a new subset of cell 
      surface-associated MMPs. The present review will focus on MT1-MMP which plays a 
      major role at least, in the ECM remodeling, directly by degrading several of its 
      components, and indirectly by activating pro-MMP2. As our knowledge on the field 
      of MT1-MMP biology has grown, the unforeseen complexities of this enzyme and its 
      interaction with its inhibitor TIMP-2 have emerged, often revealing unexpected 
      mechanisms of action.
FAU - Sounni, N E
AU  - Sounni NE
AD  - Laboratory of Tumor and Development Biology, University of Liege, Sart Tilman, 
      Belgium.
FAU - Janssen, M
AU  - Janssen M
FAU - Foidart, J M
AU  - Foidart JM
FAU - Noel, A
AU  - Noel A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Matrix Biol
JT  - Matrix biology : journal of the International Society for Matrix Biology
JID - 9432592
RN  - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
RN  - EC 3.4.24.- (Matrix Metalloproteinases, Membrane-Associated)
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - Animals
MH  - Extracellular Matrix/metabolism
MH  - Humans
MH  - Matrix Metalloproteinases, Membrane-Associated
MH  - Metalloendopeptidases/chemistry/*metabolism
MH  - Neoplasms/*blood supply/*enzymology
MH  - *Neovascularization, Pathologic
MH  - Tissue Inhibitor of Metalloproteinase-2/*metabolism
RF  - 51
EDAT- 2003/04/26 05:00
MHDA- 2004/02/03 05:00
CRDT- 2003/04/26 05:00
PHST- 2003/04/26 05:00 [pubmed]
PHST- 2004/02/03 05:00 [medline]
PHST- 2003/04/26 05:00 [entrez]
AID - S0945053X03000039 [pii]
AID - 10.1016/s0945-053x(03)00003-9 [doi]
PST - ppublish
SO  - Matrix Biol. 2003 Mar;22(1):55-61. doi: 10.1016/s0945-053x(03)00003-9.