PMID- 12715216
OWN - NLM
STAT- MEDLINE
DCOM- 20030922
LR  - 20191210
IS  - 0364-2313 (Print)
IS  - 0364-2313 (Linking)
VI  - 27
IP  - 5
DP  - 2003 May
TI  - Surgical influence on TH1/TH2 balance and monocyte surface antigen expression and 
      its relation to infectious complications.
PG  - 522-8
AB  - Malignancy and operation for it cause several alterations in immune function that 
      are considered to be concerned with the development of infectious complications. 
      Forty-three patients who underwent curative surgery for gastrointestinal 
      malignancies were entered into this study and were divided into two groups, those 
      with and those without postoperative infection. Changes in the proportion of 
      Th1/Th2 subsets in CD4(+) T cells and the expression of human leukocyte antigen 
      (HLA)-DR and CD16a molecules on monocytes were measured by flow cytometry before 
      and after surgery. We performed intracellular cytokine stainings to exactly 
      detect Th1/Th2 subsets. The proportions of interferon- gamma-producing CD4(+) T 
      (Th1) cells in the preoperative state were almost equal in the two groups, and 
      the proportion decreased on postoperative day (POD) 1 in both groups. On POD 7, 
      the proportion of Th1 cells recovered to the preoperative level in the 
      noninfection group, while the suppression was further reinforced in the infection 
      group (26.8% versus 18.3%, p < 0.005). In contrast, the proportion of 
      interleukin-4-producing CD4(+) T (Th2) cells in the infection group (11.3%) was 
      already suppressed in the preoperative state when compared with the noninfection 
      group (17.3%, p < 0.005). Changes in HLA-DR and CD16a expression on monocytes 
      were similar to the changes in the proportion of Th1 cells. These results 
      indicate that the suppression of Th1 cell and monocyte functions during the early 
      phase of the postoperative course was directly related to the occurrence of 
      infectious complications and that several immunological impairments have already 
      occurred in the preoperative state in cancer patients.
FAU - Tatsumi, Hiroomi
AU  - Tatsumi H
AD  - First Department of Surgery, Sapporo Medical University School of Medicine, South 
      1, West 16, Chuo-ku, Sapporo 060-8543, Japan. htatsumi@sapmed.ac.jp
FAU - Ura, Hideki
AU  - Ura H
FAU - Ikeda, Shinichiro
AU  - Ikeda S
FAU - Yamaguchi, Koji
AU  - Yamaguchi K
FAU - Katsuramaki, Tadashi
AU  - Katsuramaki T
FAU - Asai, Yasufumi
AU  - Asai Y
FAU - Hirata, Koichi
AU  - Hirata K
LA  - eng
PT  - Journal Article
DEP - 20030428
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
RN  - 0 (Antigens, Surface)
RN  - 0 (Cytokines)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, Surface/*metabolism
MH  - Cytokines/blood
MH  - Female
MH  - Flow Cytometry
MH  - Gastrointestinal Neoplasms/*surgery
MH  - Humans
MH  - Infections/*immunology
MH  - Interleukin-4/blood
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*immunology
MH  - Postoperative Complications/*immunology
MH  - Th1 Cells/*metabolism
MH  - Th2 Cells/*metabolism
EDAT- 2003/04/26 05:00
MHDA- 2003/09/23 05:00
CRDT- 2003/04/26 05:00
PHST- 2003/04/26 05:00 [pubmed]
PHST- 2003/09/23 05:00 [medline]
PHST- 2003/04/26 05:00 [entrez]
AID - 10.1007/s00268-003-6813-2 [doi]
PST - ppublish
SO  - World J Surg. 2003 May;27(5):522-8. doi: 10.1007/s00268-003-6813-2. Epub 2003 Apr 
      28.