PMID- 12716411
OWN - NLM
STAT- MEDLINE
DCOM- 20030813
LR  - 20190922
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 15
IP  - 6
DP  - 2003 Jun
TI  - Oestrogen-induced vigorous mounting in female rats carrying hypothalamic knife 
      cuts.
PG  - 602-6
AB  - In ovariectomized Wistar rats, 1- or 2-mm wide knife cuts were placed in a 
      coronal plane from the surface of the cortex to the floor of the cranial cavity 
      to interrupt posterior efferents of the ventromedial nucleus of the hypothalamus 
      (VMN). Sham-operated females had the same knife lowered to a depth of 7 mm. 
      Ovariectomized nonoperated females were also used. After recovery, all rats 
      received a single injection of 2 microg oestradiol benzoate, and were tested 48 h 
      later for male and female sexual behaviour and partner preference. When placed 
      with highly receptive stimulus females, the rats with the 2-mm cut showed a 
      significantly higher incidence of mounting with ejaculatory thrusts than any 
      other groups. When placed with stud males, 1-mm cut, as well as sham-operated 
      females, had increased lordosis quotients. Similarly, both 1-mm and 2-mm cuts and 
      sham operation enhanced the incidence of ear wiggling. Despite the display of a 
      transsexual behaviour (i.e. vigorous mounting), all females with the cut showed 
      heterosexual partner preference. Thus, the cut in the present study removed the 
      inhibitory neural effect on mounting, which presumably descends from the VMN. In 
      the absence of this inhibition, minute amounts of oestrogen sufficed to induce 
      vigorous mounting. Sham operation in the present study appeared to interfere with 
      certain inhibitory neural circuitry for lordosis.
FAU - Ohnishi, H
AU  - Ohnishi H
AD  - Department of Physiology, Nippon Medical School, Bunkyo, Tokyo 113-8602, Japan.
FAU - Kondo, Y
AU  - Kondo Y
FAU - Sakuma, Y
AU  - Sakuma Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Estradiol/*physiology
MH  - Female
MH  - Hypothalamus/injuries/*physiopathology/surgery
MH  - Male
MH  - Ovariectomy
MH  - Rats
MH  - Sexual Behavior, Animal/*physiology
EDAT- 2003/04/30 05:00
MHDA- 2003/08/14 05:00
CRDT- 2003/04/30 05:00
PHST- 2003/04/30 05:00 [pubmed]
PHST- 2003/08/14 05:00 [medline]
PHST- 2003/04/30 05:00 [entrez]
AID - 1040 [pii]
AID - 10.1046/j.1365-2826.2003.01040.x [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2003 Jun;15(6):602-6. doi: 10.1046/j.1365-2826.2003.01040.x.