PMID- 12716817
OWN - NLM
STAT- MEDLINE
DCOM- 20031218
LR  - 20220331
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 26
IP  - 5
DP  - 2003 May
TI  - Factors affecting progression of renal failure in patients with type 2 diabetes.
PG  - 1530-4
AB  - OBJECTIVE: Hyperglycemia and hypertension are known to be risk factors for the 
      development of proteinuria in patients with diabetes. Little is known, however, 
      about predictors of progression of renal failure in diabetic patients. RESEARCH 
      DESIGN AND METHODS: We investigated factors affecting progression of renal 
      failure by measuring the doubling of serum creatinine (s-Cr) as an end point in a 
      cohort of 85 type 2 diabetic patients with chronic renal insufficiency/failure 
      (s-Cr >1.5 and <3.7 mg/dl, 61 +/- 11 years old, 51 men and 34 women, mean s-Cr 
      2.3 +/- 0.6 mg/dl). RESULTS: The survey period (mean +/- SD) was 14.2 +/- 10.8 
      months. The cumulative incidence of the end point in patients with insulin 
      therapy (n = 41) was significantly lower than that in patients without it (n = 
      44) (P = 0.0022, P values by log-rank test). Multivariate Cox analysis revealed 
      insulin therapy (hazard ratio [HR] 0.435, 95% CI 0.252-0.750, P = 0.0027), serum 
      albumin (0.484, 284-0.823, P = 0.0074), mean blood pressure (1.023, 1.004-1.043, 
      P = 0.017), and hemoglobin (0.841, 0.728-0.972, P = 0.0194) to be independent and 
      significant predictors of progression to renal failure, whereas HbA(1c) or serum 
      cholesterol were not. CONCLUSION: In type 2 diabetic patients with renal failure, 
      hypoalbuminemia, anemia, higher mean blood pressure, and lack of use of insulin 
      predict rapid progression of renal failure, but HbA(1c) does not, and insulin 
      therapy may be possibly an indicator of the delay in progression of renal 
      failure.
FAU - Ueda, Hideki
AU  - Ueda H
AD  - Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City 
      University Graduate School of Medicine, Japan.
FAU - Ishimura, Eiji
AU  - Ishimura E
FAU - Shoji, Tetsuo
AU  - Shoji T
FAU - Emoto, Masanori
AU  - Emoto M
FAU - Morioka, Tomoaki
AU  - Morioka T
FAU - Matsumoto, Naoki
AU  - Matsumoto N
FAU - Fukumoto, Shinya
AU  - Fukumoto S
FAU - Miki, Takami
AU  - Miki T
FAU - Inaba, Masaaki
AU  - Inaba M
FAU - Nishizawa, Yoshiki
AU  - Nishizawa Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Serum Albumin)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Age of Onset
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Cholesterol/blood
MH  - Cohort Studies
MH  - Creatinine/*blood
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Diabetic Neuropathies/physiopathology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kidney Failure, Chronic/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Serum Albumin/analysis
MH  - Time Factors
MH  - Triglycerides/blood
EDAT- 2003/04/30 05:00
MHDA- 2003/12/19 05:00
CRDT- 2003/04/30 05:00
PHST- 2003/04/30 05:00 [pubmed]
PHST- 2003/12/19 05:00 [medline]
PHST- 2003/04/30 05:00 [entrez]
AID - 10.2337/diacare.26.5.1530 [doi]
PST - ppublish
SO  - Diabetes Care. 2003 May;26(5):1530-4. doi: 10.2337/diacare.26.5.1530.