PMID- 12716957
OWN - NLM
STAT- MEDLINE
DCOM- 20030530
LR  - 20200225
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 23
IP  - 8
DP  - 2003 Apr 15
TI  - A critical role for nucleus accumbens dopamine in partner-preference formation in 
      male prairie voles.
PG  - 3483-90
AB  - Although the role of nucleus accumbens (NAcc) dopamine (DA) in reward learning 
      has been extensively studied, few investigations have addressed its involvement 
      in learning socially relevant information. Here, we have examined the involvement 
      of NAcc DA in social attachment of the "monogamous" prairie vole (Microtus 
      orchrogaster). We first demonstrated that DA is necessary for the formation of 
      social attachment in male prairie voles, because administration of haloperidol 
      blocked, whereas apomorphine induced, partner-preference formation. We then 
      provided the first descriptions of DA neuroanatomy and tissue content in vole 
      NAcc, and mating appeared to induce a 33% increase in DA turnover. We also showed 
      that administration of haloperidol directly into the NAcc blocked partner 
      preferences induced by mating and apomorphine. In addition, administration of 
      apomorphine into the NAcc but not the caudate putamen induced partner preferences 
      in the absence of mating. Together, our data support the hypothesis that NAcc DA 
      is critical for pair-bond formation in male prairie voles.
FAU - Aragona, Brandon J
AU  - Aragona BJ
AD  - Department of Psychology and Program in Neuroscience, Florida State University, 
      Tallahassee, Florida 32306-1270, USA. aragona@psy.fsu.edu
FAU - Liu, Yan
AU  - Liu Y
FAU - Curtis, J Thomas
AU  - Curtis JT
FAU - Stephan, Friedrich K
AU  - Stephan FK
FAU - Wang, Zuoxin
AU  - Wang Z
LA  - eng
GR  - MH-66734/MH/NIMH NIH HHS/United States
GR  - MH-67396/MH/NIMH NIH HHS/United States
GR  - R01 MH058616/MH/NIMH NIH HHS/United States
GR  - F31 MH067396/MH/NIMH NIH HHS/United States
GR  - R21 MH066734/MH/NIMH NIH HHS/United States
GR  - MH-58616/MH/NIMH NIH HHS/United States
GR  - HD-40722/HD/NICHD NIH HHS/United States
GR  - F32 HD040722/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Dopamine Agonists)
RN  - 0 (Dopamine Antagonists)
RN  - J6292F8L3D (Haloperidol)
RN  - N21FAR7B4S (Apomorphine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Apomorphine/pharmacology
MH  - Arvicolinae/*physiology
MH  - Caudate Nucleus/drug effects
MH  - Dopamine/*metabolism
MH  - Dopamine Agonists/pharmacology
MH  - Dopamine Antagonists/pharmacology
MH  - Drug Administration Routes
MH  - Female
MH  - Haloperidol/pharmacology
MH  - Learning/physiology
MH  - Male
MH  - Nucleus Accumbens/anatomy & histology/drug effects/*physiology
MH  - *Pair Bond
MH  - Putamen/drug effects
MH  - Sexual Behavior, Animal/drug effects/*physiology
PMC - PMC6742315
EDAT- 2003/04/30 05:00
MHDA- 2003/05/31 05:00
PMCR- 2003/10/15
CRDT- 2003/04/30 05:00
PHST- 2003/04/30 05:00 [pubmed]
PHST- 2003/05/31 05:00 [medline]
PHST- 2003/04/30 05:00 [entrez]
PHST- 2003/10/15 00:00 [pmc-release]
AID - 23/8/3483 [pii]
AID - 7499 [pii]
AID - 10.1523/JNEUROSCI.23-08-03483.2003 [doi]
PST - ppublish
SO  - J Neurosci. 2003 Apr 15;23(8):3483-90. doi: 10.1523/JNEUROSCI.23-08-03483.2003.