PMID- 12718074
OWN - NLM
STAT- MEDLINE
DCOM- 20030620
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 61
IP  - 4
DP  - 2003 Apr
TI  - [Idiopathic thrombocytopenic purpura].
PG  - 552-7
AB  - Idiopathic(autoimmune) thrombocytopenic purpura(ITP) is characterized by 
      thrombocytopenia and normal to increased numbers of megakaryocytes. ITP is a 
      disease caused by circulating autoantibodies that react with the platelet 
      membrane. It is thought that platelet-associated IgG(PAIgG) plays an important 
      role in the mechanism of ITP, since increases in PAIgG are closely related to 
      decreases in platelet count in patients with this disease. However, it is 
      possible that PAIgG includes immune complex and platelet antibodies to human 
      platelet alloantigens(HPA) other than autoantibodies. There have been several 
      recent reports on autoantibodies to glycoprotein IIb/IIIa and Ib/IX. Although the 
      etiology of ITP remains unclear, both genetic and environmental factors appear to 
      be involved in it. With respect to the genetic aspects of ITP, the human 
      leukocyte antigen (HLA) haplotype of patients is considered a potentially 
      important factor in etiology. Various methods have been used for the treatment of 
      chronic ITP. However, splenectomy and corticosteroids are still the mainstays of 
      therapy. Because of the heterogeneity of the disease, however, approximately 20% 
      of cases are refractory to these treatments. New therapy of chronic or refractory 
      ITP with thrombopoietin, antiCD40 ligand antibody, and Helicobactor pylori 
      eradication have recently been reported.
FAU - Nomura, Shosaku
AU  - Nomura S
AD  - Department of Internal Medicine, Kohri Hospital, Kansai Medical University.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - Humans
MH  - *Purpura, Thrombocytopenic, Idiopathic/immunology
RF  - 19
EDAT- 2003/04/30 05:00
MHDA- 2003/06/21 05:00
CRDT- 2003/04/30 05:00
PHST- 2003/04/30 05:00 [pubmed]
PHST- 2003/06/21 05:00 [medline]
PHST- 2003/04/30 05:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 2003 Apr;61(4):552-7.