PMID- 12719801
OWN - NLM
STAT- MEDLINE
DCOM- 20040527
LR  - 20151119
IS  - 0934-0874 (Print)
IS  - 0934-0874 (Linking)
VI  - 16
IP  - 8
DP  - 2003 Aug
TI  - Increased expression of p21 (WAF1/CIP1) cyclin-dependent kinase (CDK) inhibitor 
      gene in chronic allograft nephropathy correlates with the number of acute 
      rejection episodes.
PG  - 502-6
AB  - The p21 (WAF1/CIP1) cyclin-dependent kinase (CDK) inhibitor gene is considered to 
      be the senescence marker in some recent publications. Expression of the gene was 
      evaluated in 14 normal human kidney tissues of different ages and in nine 
      chronically rejected renal allografts. All normal kidneys were negative for p21 
      expression. Glomerular, tubular and interstitial expression of the marker was 
      detected in 88.9% ( P<0.0001) and vascular expression in 66.7% of chronically 
      rejected grafts ( P<0.001). No correlation was found between the intensity of p21 
      expression and recipient age, donor age or number of human leukocyte antigen 
      (HLA) mismatches. The marker was expressed more in grade 3 of chronic allograft 
      nephropathy (CAN) than in grade 2 ( P=0.059 for glomerular score). Tubular 
      expression of p21 was correlated with the number of acute rejections: P<0.05 for 
      three vs one and two, and P=0.0046 for three vs no previous acute rejection 
      episodes.
FAU - Chkhotua, Archil B
AU  - Chkhotua AB
AD  - National Center of Urology, Tsinandali St 9, 380044, Tbilisi, Georgia. 
      achkhotua@hotmail.com
FAU - Altimari, Annalisa
AU  - Altimari A
FAU - Gabusi, Elena
AU  - Gabusi E
FAU - D'Errico, Antonia
AU  - D'Errico A
FAU - Stefoni, Sergio
AU  - Stefoni S
FAU - Chieco, Pasquale
AU  - Chieco P
FAU - Yakubovich, Michaela
AU  - Yakubovich M
FAU - Vienken, Joerg
AU  - Vienken J
FAU - Yussim, Alexander
AU  - Yussim A
FAU - Grigioni, Walter F
AU  - Grigioni WF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030429
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - 0 (Biomarkers)
RN  - 0 (CDKN1A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (Cyclins)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Biomarkers
MH  - Chronic Disease
MH  - Cyclin-Dependent Kinase Inhibitor p21
MH  - Cyclins/*metabolism
MH  - Female
MH  - Graft Rejection/*diagnosis/*metabolism
MH  - Humans
MH  - Kidney/*metabolism
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Transplantation, Homologous
MH  - Up-Regulation
EDAT- 2003/04/30 05:00
MHDA- 2004/05/28 05:00
CRDT- 2003/04/30 05:00
PHST- 2002/02/28 00:00 [received]
PHST- 2003/02/04 00:00 [revised]
PHST- 2003/02/14 00:00 [accepted]
PHST- 2003/04/30 05:00 [pubmed]
PHST- 2004/05/28 05:00 [medline]
PHST- 2003/04/30 05:00 [entrez]
AID - 10.1007/s00147-003-0587-1 [doi]
PST - ppublish
SO  - Transpl Int. 2003 Aug;16(8):502-6. doi: 10.1007/s00147-003-0587-1. Epub 2003 Apr 
      29.