PMID- 12720126
OWN - NLM
STAT- MEDLINE
DCOM- 20030602
LR  - 20041117
IS  - 0093-7754 (Print)
IS  - 0093-7754 (Linking)
VI  - 30
IP  - 2
DP  - 2003 Apr
TI  - 14q32 Translocations discriminate IgM multiple myeloma from Waldenstrom's 
      macroglobulinemia.
PG  - 153-5
AB  - Even though the diagnosis of Waldenstrom's macroglobulinemia WM is usually clear, 
      the differential diagnosis with IgM multiple myeloma (MM) might be possible. IgM 
      MM is usually characterized by the accumulation of small mature plasma cells 
      within the bone marrow, and the detection of a monoclonal IgM in the serum. 
      However, in contrast with classical MM, IgM MM is rarely associated with these 
      patients' extensive osteolytic lesions. We analyzed eight cases of IgM MM. None 
      presented with extensive bone lesions. All cases were characterized by the 
      presence of small mature plasma cells within the bone marrow. Molecular 
      cytogenetic analysis revealed a t(11;14) in seven of the eight cases. In 
      contrast, a similar analysis in 17 WM cases failed to detect any t(11;14) cases. 
      We performed further fluorescence in situ hybridization (FISH) experiments, 
      focused on the 14q32 region, and especially on the IgH gene. In contrast to MM 
      (in which illegitimate IgH rearrangements are common), we did not detect any 
      abnormality in the WM cases. In conclusion, even though the cells of origin in WM 
      and MM are mature heavily mutated cells, they differ by the IgH gene 
      rearrangements. Especially in IgM MM, the search for t(11;14) might be useful in 
      difficult cases to discriminate with WM.
CI  - Copyright 2003 Elsevier Inc. All rights reserved.
FAU - Avet-Loiseau, Herve
AU  - Avet-Loiseau H
AD  - Laboratory of Hematology, University Hospital, Nantes, France.
FAU - Garand, Richard
AU  - Garand R
FAU - Lode, Laurence
AU  - Lode L
FAU - Robillard, Nelly
AU  - Robillard N
FAU - Bataille, Regis
AU  - Bataille R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Semin Oncol
JT  - Seminars in oncology
JID - 0420432
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Diagnosis, Differential
MH  - *Gene Rearrangement, B-Lymphocyte, Heavy Chain
MH  - Genes, Immunoglobulin
MH  - Humans
MH  - Immunoglobulin M/*immunology
MH  - In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Multiple Myeloma/*diagnosis/*genetics/immunology
MH  - Mutation
MH  - *Translocation, Genetic
MH  - Waldenstrom Macroglobulinemia/*diagnosis/*genetics/immunology
EDAT- 2003/04/30 05:00
MHDA- 2003/06/05 05:00
CRDT- 2003/04/30 05:00
PHST- 2003/04/30 05:00 [pubmed]
PHST- 2003/06/05 05:00 [medline]
PHST- 2003/04/30 05:00 [entrez]
AID - S0093775403000204 [pii]
AID - 10.1053/sonc.2003.50053 [doi]
PST - ppublish
SO  - Semin Oncol. 2003 Apr;30(2):153-5. doi: 10.1053/sonc.2003.50053.