PMID- 12722556
OWN - NLM
STAT- MEDLINE
DCOM- 20030813
LR  - 20131121
IS  - 0003-9225 (Print)
IS  - 0003-9225 (Linking)
VI  - 211
IP  - 3-4
DP  - 2003 Mar-Apr
TI  - [Fatal outcome of Ecstasy overdose].
PG  - 73-80
AB  - Consumption of amphetamine derivatives has considerably increased in Germany 
      since the early nineties. Again and again intoxications with lethal outcome have 
      also been reported, especially after physical activities such as intensive 
      dancing. The authors present a case of an obviously suicidal intoxication of a 
      21-year-old man who was found dead with marked cuts on the right forearm. 
      Toxicological tests showed in particular 3, 4-methylene-dioxymethamphetamine 
      (MDMA). The results of the hair analysis revealed chronic consumption, but no 
      cellular liver damage could be demonstrated. When examining the body fluids and 
      organs, the highest concentrations by far were measured in the lungs (36.6 
      mg/kg), the liver (29.7 mg/kg) and the brain (29.1 mg/kg). The concentration in 
      heart blood amounted to 10.8 mg/kg and was thus markedly higher than in 
      peripheral blood (7.2 mg/kg). In the muscles concentrations ranged between 14.3 
      mg/kg and 20.2 mg/kg. On the basis of these concentrations and the available 
      pharmacokinetic data the amount of MDMA probably consumed is assessed. It is 
      demonstrated that for this assessment the concentrations in the muscular system 
      are of special importance, as redistribution of highly lipophilic substances from 
      the surrounding tissue is possible also in peripheral blood.
FAU - Sticht, Guido
AU  - Sticht G
AD  - Institut fur Rechtsmedizin, Universitat zu Koln.
FAU - Pluisch, Frank
AU  - Pluisch F
FAU - Bierhoff, Erhard
AU  - Bierhoff E
FAU - Kaferstein, Herbert
AU  - Kaferstein H
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Todesfall nach Ecstasy-Uberdosierung.
PL  - Germany
TA  - Arch Kriminol
JT  - Archiv fur Kriminologie
JID - 0002256
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Autopsy
MH  - Cause of Death
MH  - Diagnosis, Differential
MH  - Drug Overdose/blood/*pathology
MH  - Hair/chemistry
MH  - Homicide/legislation & jurisprudence
MH  - Humans
MH  - Male
MH  - Mass Spectrometry
MH  - Metabolic Clearance Rate
MH  - N-Methyl-3,4-methylenedioxyamphetamine/analysis/pharmacokinetics/*poisoning
MH  - Substance-Related Disorders/pathology
MH  - Tissue Distribution
EDAT- 2003/05/02 05:00
MHDA- 2003/08/14 05:00
CRDT- 2003/05/02 05:00
PHST- 2003/05/02 05:00 [pubmed]
PHST- 2003/08/14 05:00 [medline]
PHST- 2003/05/02 05:00 [entrez]
PST - ppublish
SO  - Arch Kriminol. 2003 Mar-Apr;211(3-4):73-80.