PMID- 12725894
OWN - NLM
STAT- MEDLINE
DCOM- 20030606
LR  - 20190719
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 60
IP  - 1-2
DP  - 2003 Apr 15
TI  - Metabotropic glutamate receptor-mediated hetero-synaptic interaction of red- and 
      green-cone inputs to LHC of carp retina.
PG  - 67-71
AB  - The role of presynaptic metabotropic glutamate receptor (mGluR) on the 
      interaction of red- and green-cone signals was investigated in luminosity-type 
      horizontal cell (LHC) of isolated carp retina. It was found that a dim red 
      background could enhance LHC's light response to green stimulus, and a dim green 
      background was also able to increase the cell's response to red flash. Such 
      mutual color enhancement was eliminated by application of groups II and III mGluR 
      antagonist (S)-methyl-4-carboxyphenyl-glycine (MCPG). Furthermore, inhibition of 
      glutamate uptake by using D-aspartate (D-Asp) or DL-threo-beta-hydroxy-aspartic 
      acid (THA) completely blocked the mutual enhancement of color signals in LHC. 
      However, the GABAergic feedback pathway in the outer retina was unnecessarily 
      involved.
FAU - Luo, Fu-Jun
AU  - Luo FJ
AD  - Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, 
      Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, PR China.
FAU - Liang, Pei-Ji
AU  - Liang PJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (GABA Antagonists)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (carboxyphenylglycine)
RN  - 124-87-8 (Picrotoxin)
RN  - 1860-87-3 (3-hydroxyaspartic acid)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 4SR0Q8YD1X (D-Aspartic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Animals
MH  - Aspartic Acid/analogs & derivatives/pharmacology
MH  - Carps
MH  - Color
MH  - D-Aspartic Acid/pharmacology
MH  - GABA Antagonists/pharmacology
MH  - Glycine/*analogs & derivatives/pharmacology
MH  - In Vitro Techniques
MH  - Interneurons/drug effects
MH  - Membrane Potentials/drug effects
MH  - Photic Stimulation
MH  - Picrotoxin/pharmacology
MH  - Receptors, Metabotropic Glutamate/agonists/antagonists & inhibitors/*physiology
MH  - Retina/*cytology/drug effects
MH  - Retinal Cone Photoreceptor Cells/*physiology
MH  - gamma-Aminobutyric Acid/pharmacology
EDAT- 2003/05/03 05:00
MHDA- 2003/06/07 05:00
CRDT- 2003/05/03 05:00
PHST- 2003/05/03 05:00 [pubmed]
PHST- 2003/06/07 05:00 [medline]
PHST- 2003/05/03 05:00 [entrez]
AID - S0361923003000157 [pii]
AID - 10.1016/s0361-9230(03)00015-7 [doi]
PST - ppublish
SO  - Brain Res Bull. 2003 Apr 15;60(1-2):67-71. doi: 10.1016/s0361-9230(03)00015-7.