PMID- 12725902
OWN - NLM
STAT- MEDLINE
DCOM- 20030606
LR  - 20190719
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 60
IP  - 1-2
DP  - 2003 Apr 15
TI  - Induction of Fos in the accessory olfactory system by male odors persists in 
      female mice with a null mutation of the aromatase (cyp19) gene.
PG  - 143-50
AB  - The ability of odors from soiled male bedding to induce neuronal 
      Fos-immunoreactivity (IR) in sensory neurons located in both the apical and basal 
      zones of the vomeronasal organ (VNO) and in two segments of the VNO-projection 
      pathway, the anterior nucleus of the medial amygdala and the bed nucleus of the 
      stria terminalis (BNST), was significantly reduced in adult, ovariectomized, 
      estrogen-treated female mice with a homozygous null mutation of the cyp19 gene 
      (ArKO) which encodes the estrogen biosynthetic P450 enzyme, aromatase. However, a 
      significant odor-induced activation of Fos-IR was seen in other segments of the 
      VNO-projection pathway of ArKO females, including the accessory olfactory bulb 
      (AOB) granule cell layer, the posterior-dorsal medial amygdala (MePD), and the 
      medial preoptic area (MPA). These results suggest that the VNO/accessory 
      olfactory pathway to the hypothalamus was functional in ArKO females even though 
      they had presumably been exposed to less estrogenic stimulation than wild-type 
      (WT) control females throughout development and until the time that estrogen 
      treatment was begun in adulthood. Thus, the hypothesis of Toran-Allerand [Prog. 
      Brain Res. 61 (1984) 63] that female-typical features of neuroendocrine and 
      behavioral function require perinatal exposure to estrogen was not supported, at 
      least for the VNO/accessory olfactory system.
FAU - Lau, Y E
AU  - Lau YE
AD  - Department of Biology, Boston University, Cummington St., Boston, MA 02215, USA.
FAU - Cherry, J A
AU  - Cherry JA
FAU - Baum, M J
AU  - Baum MJ
FAU - Mani, S K
AU  - Mani SK
LA  - eng
GR  - MH57442/MH/NIMH NIH HHS/United States
GR  - MH59200/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Pheromones)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 1S4CJB5ZGN (estradiol 3-benzoate)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 1.14.14.1 (Aromatase)
SB  - IM
MH  - Animals
MH  - Aromatase/*genetics
MH  - Bedding and Linens
MH  - Estradiol/administration & dosage/*analogs & derivatives
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - *Mutation
MH  - *Odorants
MH  - Olfactory Bulb/cytology/*drug effects/metabolism
MH  - Ovariectomy/methods
MH  - Pheromones/*pharmacology
MH  - Preoptic Area/cytology/drug effects/metabolism
MH  - Proto-Oncogene Proteins c-fos/*biosynthesis
MH  - Sex Factors
MH  - Stimulation, Chemical
MH  - Vomeronasal Organ/drug effects/metabolism
EDAT- 2003/05/03 05:00
MHDA- 2003/06/07 05:00
CRDT- 2003/05/03 05:00
PHST- 2003/05/03 05:00 [pubmed]
PHST- 2003/06/07 05:00 [medline]
PHST- 2003/05/03 05:00 [entrez]
AID - S0361923003000248 [pii]
AID - 10.1016/s0361-9230(03)00024-8 [doi]
PST - ppublish
SO  - Brain Res Bull. 2003 Apr 15;60(1-2):143-50. doi: 10.1016/s0361-9230(03)00024-8.