PMID- 12726825
OWN - NLM
STAT- MEDLINE
DCOM- 20030804
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 44
IP  - 7
DP  - 2003 Jun
TI  - Effects of the cocaine- and amphetamine-regulated transcript peptide on the 
      turnover of central dopaminergic neurons.
PG  - 940-8
AB  - The effects of the cocaine- and amphetamine-regulated transcript (CART) peptide 
      on central dopaminergic (DA) neurons were examined in ovariectomized, 
      estrogen-primed Sprague-Dawley rats in both the morning and afternoon. 
      Intracerebroventricular administration of 1 microg, but not lower doses of the 
      CART peptide (55-102), either in the morning or afternoon produced a prolonged 
      increase in the 3,4-dihydroxyphenylacetic acid (DOPAC) level in the median 
      eminence (ME) and a corresponding decrease of serum prolactin (PRL) levels, which 
      resulted from stimulation of tuberoinfundibular dopaminergic neurons. The CART 
      peptide stimulated DOPAC levels in the striatum (ST), nucleus accumbens (NA), 
      hypothalamic paraventricular nucleus (PVN), and periventricular (A14), but had no 
      effect in the medial prefrontal cortex (MPFC) or suprachiasmatic nucleus (SCN). 
      These effects of the CART peptide on stimulation of central DA systems and 
      inhibition of PRL levels are specific because the inactive form of the CART 
      peptide (0.1 and 1 microg) could not induce a similar response. Stimulatory 
      effects of the CART peptide on different central DA systems displayed 
      differential time-response profiles in the NA and ST, ME, and PVN and A14. These 
      findings indicate that the CART peptide may selectively regulate certain central 
      DA neuronal activities.
FAU - Shieh, K-R
AU  - Shieh KR
AD  - Institute of Neuroscience, Tzu Chi University, Hualien 970, Taiwan. 
      krshieh@mail.tcu.edu.tw
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (cocaine- and amphetamine-regulated transcript protein)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 9002-62-4 (Prolactin)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Brain Chemistry/*drug effects
MH  - Chromatography, High Pressure Liquid
MH  - Dopamine/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Electrochemistry
MH  - Female
MH  - Injections, Intraventricular
MH  - Nerve Tissue Proteins/*pharmacology
MH  - Neurons/*drug effects/metabolism
MH  - Ovariectomy
MH  - Peptide Fragments/pharmacology
MH  - Prolactin/blood
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 2003/05/03 05:00
MHDA- 2003/08/05 05:00
CRDT- 2003/05/03 05:00
PHST- 2003/05/03 05:00 [pubmed]
PHST- 2003/08/05 05:00 [medline]
PHST- 2003/05/03 05:00 [entrez]
AID - S0028390803000959 [pii]
AID - 10.1016/s0028-3908(03)00095-9 [doi]
PST - ppublish
SO  - Neuropharmacology. 2003 Jun;44(7):940-8. doi: 10.1016/s0028-3908(03)00095-9.