PMID- 12726886
OWN - NLM
STAT- MEDLINE
DCOM- 20030529
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 73
IP  - 1
DP  - 2003 May 23
TI  - Single eight-hour shift of light-dark cycle increases brain-derived neurotrophic 
      factor protein levels in the rat hippocampus.
PG  - 53-9
AB  - We previously reported that an eight hour phase advance in the light-dark (LD) 
      cycle increases sleep in rats. Brain-derived neurotrophic factor (BDNF) is 
      suggested to be one of the sleep and circadian regulating factors. We have 
      therefore observed the responses of BDNF protein in the hippocampus, cerebellum 
      and brainstem under conditions of LD change. BDNF protein was quantitatively 
      measured using an ELISA kit. Under an 8-h LD phase advance, the levels of 
      hippocampal BDNF were significantly increased on the day of the phase change, 
      while the levels in the cerebellum and brainstem remained constant. Plasma 
      corticosterone levels were not largely affected. Thus, a single LD shift acutely 
      affects hippocampal BDNF metabolism with no large stress response.
FAU - Sei, Hiroyoshi
AU  - Sei H
AD  - Department of Integrative Physiology, School of Medicine, The University of 
      Tokushima, Tokushima 770-8503, Japan. sei@basic.med.tokushima-u.ac.jp
FAU - Fujihara, Hiroaki
AU  - Fujihara H
FAU - Ueta, Yoichi
AU  - Ueta Y
FAU - Morita, Kyoji
AU  - Morita K
FAU - Kitahama, Kunio
AU  - Kitahama K
FAU - Morita, Yusuke
AU  - Morita Y
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Body Temperature/physiology
MH  - Brain Chemistry/*physiology
MH  - Brain Stem/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebellum/metabolism/physiology
MH  - *Circadian Rhythm
MH  - Corticosterone/blood
MH  - Darkness
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/*metabolism/*physiology
MH  - Jet Lag Syndrome/metabolism
MH  - Light
MH  - Male
MH  - Rats
MH  - Rats, Wistar
EDAT- 2003/05/03 05:00
MHDA- 2003/05/30 05:00
CRDT- 2003/05/03 05:00
PHST- 2003/05/03 05:00 [pubmed]
PHST- 2003/05/30 05:00 [medline]
PHST- 2003/05/03 05:00 [entrez]
AID - S0024320503002510 [pii]
AID - 10.1016/s0024-3205(03)00251-0 [doi]
PST - ppublish
SO  - Life Sci. 2003 May 23;73(1):53-9. doi: 10.1016/s0024-3205(03)00251-0.