PMID- 12727141
OWN - NLM
STAT- MEDLINE
DCOM- 20040309
LR  - 20191107
IS  - 1471-4914 (Print)
IS  - 1471-4914 (Linking)
VI  - 9
IP  - 4
DP  - 2003 Apr
TI  - A fatal attraction: Mycobacterium tuberculosis and HIV-1 target DC-SIGN to escape 
      immune surveillance.
PG  - 153-9
AB  - Dendritic cells (DCs) are vital in the defense against pathogens. However, it is 
      becoming increasingly clear that some pathogens subvert DC functions to escape 
      immune surveillance. For example, HIV-1 targets the DC-specific C-type lectin 
      DC-SIGN (DC-specific intercellular-adhesion-molecule-3-grabbing nonintegrin) to 
      hijack DCs for viral dissemination. Binding to DC-SIGN protects HIV-1 from 
      antigen processing and facilitates its transport to lymphoid tissues, where 
      DC-SIGN promotes HIV-1 infection of T cells. Recent studies demonstrate that 
      DC-SIGN is a universal pathogen receptor that also recognizes Ebola, 
      cytomegalovirus and mycobacteria. Mycobacterium tuberculosis targets DC-SIGN by a 
      mechanism that is distinct from that of HIV-1, leading to inhibition of the 
      immunostimulatory function of DC and, hence, promotion of pathogen survival. A 
      better understanding of DC-SIGN-pathogen interactions and their effects on DC 
      function should help to combat infections.
FAU - van Kooyk, Yvette
AU  - van Kooyk Y
AD  - Department of Molecular Cell Biology, Vrije Universiteit Medical Center 
      Amsterdam, v.d. Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
FAU - Appelmelk, Ben
AU  - Appelmelk B
FAU - Geijtenbeek, Teunis B H
AU  - Geijtenbeek TB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Mol Med
JT  - Trends in molecular medicine
JID - 100966035
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Cell Surface)
RN  - PHA4727WTP (Mannose)
SB  - IM
MH  - Cell Adhesion Molecules/*immunology/metabolism
MH  - Dendritic Cells/*immunology/metabolism/virology
MH  - HIV-1/immunology/*metabolism
MH  - Humans
MH  - *Immunologic Surveillance
MH  - Lectins, C-Type/*immunology/metabolism
MH  - Mannose/metabolism
MH  - Mycobacterium tuberculosis/immunology/*metabolism
MH  - Receptors, Cell Surface/*immunology/metabolism
MH  - T-Lymphocytes/immunology/metabolism
RF  - 53
EDAT- 2003/05/03 05:00
MHDA- 2004/03/10 05:00
CRDT- 2003/05/03 05:00
PHST- 2003/05/03 05:00 [pubmed]
PHST- 2004/03/10 05:00 [medline]
PHST- 2003/05/03 05:00 [entrez]
AID - S1471491403000273 [pii]
AID - 10.1016/s1471-4914(03)00027-3 [doi]
PST - ppublish
SO  - Trends Mol Med. 2003 Apr;9(4):153-9. doi: 10.1016/s1471-4914(03)00027-3.