PMID- 12730013
OWN - NLM
STAT- MEDLINE
DCOM- 20030710
LR  - 20190901
IS  - 0165-2427 (Print)
IS  - 0165-2427 (Linking)
VI  - 92
IP  - 3-4
DP  - 2003 May 12
TI  - Identification and characterization of auto-anti-idiotypic antibodies specific 
      for antibodies against porcine reproductive and respiratory syndrome virus 
      envelope glycoprotein (GP5).
PG  - 125-35
AB  - Auto-anti-idiotypic antibodies (Aab-2s) were detected from pigs experimentally 
      infected with porcine reproductive and respiratory syndrome virus (PRRSV). The 
      Aab-2s were specific against the idiotypic antibodies (Ab-1s) to the envelope 
      glycoprotein GP5 of PRRSV and were detected from serum samples collected between 
      21 and 98 days post-infection (DPI). Serological characterization indicated that 
      the Aab-2s recognized the idiotype located within or near the antigen-combining 
      sites of the anti-GP5 antibodies, which was shared by both mouse MAb anti-GP5 and 
      swine polyclonal antibodies. The fact that the Aab-2 inhibited the anti-GP5 
      antibodies from binding to PRRSV and that they were detected at different time 
      periods in pigs that cleared the infection prior to 98 DPI versus pigs in which 
      virus was detected at 98 DPI suggests that Aab-2 antibodies may play a role in 
      immunity to PRRSV infection.
FAU - Jiang, Zhengjun
AU  - Jiang Z
AD  - Department of Veterinary Diagnostic and Production Animal Medicine, College of 
      Veterinary Medicine, Iowa State University, Ames, IA, USA. ezhou@iastate.edu
FAU - Zhou, En-Min
AU  - Zhou EM
FAU - Ameri-Mahabadi, Mehrdad
AU  - Ameri-Mahabadi M
FAU - Zimmerman, Jeffrey J
AU  - Zimmerman JJ
FAU - Platt, Kenneth B
AU  - Platt KB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Vet Immunol Immunopathol
JT  - Veterinary immunology and immunopathology
JID - 8002006
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Autoantibodies)
RN  - 0 (Glycoproteins)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
MH  - Animals
MH  - Antibodies, Anti-Idiotypic/blood/*immunology
MH  - Antibodies, Monoclonal/immunology
MH  - Antibodies, Viral/blood/*immunology
MH  - Antibody Specificity
MH  - Autoantibodies/blood/immunology
MH  - Blotting, Western/veterinary
MH  - Enzyme-Linked Immunosorbent Assay/veterinary
MH  - Fluorescent Antibody Technique, Indirect/veterinary
MH  - Glycoproteins/immunology
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Swine
MH  - Viral Envelope Proteins/*immunology
EDAT- 2003/05/06 05:00
MHDA- 2003/07/11 05:00
CRDT- 2003/05/06 05:00
PHST- 2003/05/06 05:00 [pubmed]
PHST- 2003/07/11 05:00 [medline]
PHST- 2003/05/06 05:00 [entrez]
AID - S0165242703000229 [pii]
AID - 10.1016/s0165-2427(03)00022-9 [doi]
PST - ppublish
SO  - Vet Immunol Immunopathol. 2003 May 12;92(3-4):125-35. doi: 
      10.1016/s0165-2427(03)00022-9.