PMID- 12734352
OWN - NLM
STAT- MEDLINE
DCOM- 20030826
LR  - 20190516
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 170
IP  - 10
DP  - 2003 May 15
TI  - Early IL-2 production by mouse dendritic cells is the result of microbial-induced 
      priming.
PG  - 5075-81
AB  - Dendritic cells (DCs) are professional APCs able to initiate innate and adaptive 
      immune responses against invading pathogens. Different properties such as the 
      efficient Ag processing machinery, the high levels of expression of costimulatory 
      molecules and peptide-MHC complexes, and the production of cytokines contribute 
      in making DCs potent stimulators of naive T cell responses. Recently we have 
      observed that DCs are able to produce IL-2 following bacterial stimulation, and 
      we have demonstrated that this particular cytokine is a key molecule conferring 
      to early bacterial activated DCs unique T cell priming capacity. In the present 
      study we show that many different microbial stimuli, but not inflammatory 
      cytokines, are able to stimulate DCs to produce IL-2, indicating that DCs can 
      distinguish a cytokine-mediated inflammatory process from the actual presence of 
      an infection. The capacity to produce IL-2 following a microbial stimuli 
      encounter is a feature shared by diverse DC subtypes in vivo, such as CD8 
      alpha(+) and CD8 alpha(-) splenic DCs and epidermal Langerhans cells. When early 
      activated DCs interact with T cells, IL-2 produced by DCs is enriched at the site 
      of cell-cell contact, confirming the importance of DCs-derived IL-2 in T cell 
      activation.
FAU - Granucci, Francesca
AU  - Granucci F
AD  - Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, 
      Italy.
FAU - Feau, Sonia
AU  - Feau S
FAU - Angeli, Veronique
AU  - Angeli V
FAU - Trottein, Francois
AU  - Trottein F
FAU - Ricciardi-Castagnoli, Paola
AU  - Ricciardi-Castagnoli P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Interleukin-2)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Peptidoglycan)
RN  - 0 (Teichoic Acids)
RN  - 56411-57-5 (lipoteichoic acid)
RN  - 9010-72-4 (Zymosan)
SB  - IM
MH  - Animals
MH  - Cell Communication/immunology
MH  - Cell Line
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology/metabolism/*microbiology
MH  - Escherichia coli/immunology
MH  - *Immunization/methods
MH  - Injections, Intraperitoneal
MH  - Interleukin-2/*biosynthesis/metabolism
MH  - Lipopolysaccharides/administration & dosage/immunology
MH  - Lymphoid Tissue/immunology/metabolism
MH  - Melanoma, Experimental
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Peptidoglycan/immunology
MH  - Phagocytosis/immunology
MH  - T-Lymphocytes/immunology
MH  - Teichoic Acids/immunology
MH  - Tumor Cells, Cultured
MH  - Zymosan/immunology
EDAT- 2003/05/08 05:00
MHDA- 2003/08/27 05:00
CRDT- 2003/05/08 05:00
PHST- 2003/05/08 05:00 [pubmed]
PHST- 2003/08/27 05:00 [medline]
PHST- 2003/05/08 05:00 [entrez]
AID - 10.4049/jimmunol.170.10.5075 [doi]
PST - ppublish
SO  - J Immunol. 2003 May 15;170(10):5075-81. doi: 10.4049/jimmunol.170.10.5075.