PMID- 12734704
OWN - NLM
STAT- MEDLINE
DCOM- 20040109
LR  - 20181113
IS  - 0340-0131 (Print)
IS  - 0340-0131 (Linking)
VI  - 76
IP  - 5
DP  - 2003 Jun
TI  - Occupational issues of allergic contact dermatitis.
PG  - 347-50
AB  - Occupational contact dermatitis is often of multifactorial origin, and it is 
      difficult to determine the relative significance of the various contributing 
      factors. Contact allergies are relevant in 20-50% of recognised occupational 
      contact dermatitis cases. The reported frequency in different studies varies, 
      depending on differences in how occupational diseases are notified and 
      recognised, in types of occupation in a geographical area, and the "quality" of 
      the dermatological examination, including the accuracy of the diagnostic 
      patch-test investigation. However, the clinical relevance of the reported contact 
      allergies is often uncertain. Many occupational contact dermatitis patients with 
      documented contact allergies develop chronic eczema, in spite of work changes and 
      attempted allergen avoidance. Recognition/non-recognition of a notified case may 
      be based on circumstantial evidence, because of difficulties in the establishing 
      of a firm proof of work exposure and subsequent development of skin disease. 
      Reliable quantitative exposure measuring techniques are needed. Methods are 
      developed for the measurement of exposure to allergens such as nickel and 
      acrylates, which makes it possible for exposure-effect relationships to be 
      established with increased certainty. For prevention of allergic contact 
      dermatitis it was a major step forward, with mandatory ingredient labelling of 
      cosmetic products. However, improved labelling of the presence of contact 
      allergens in household and industrial products is needed. For the identification 
      of hazardous contact allergenic compounds, guinea pig or mice assays are still 
      required. The local lymph node assay (LLNA), which is an objective and sensitive 
      mouse assay has now been internationally validated and accepted.
FAU - Andersen, Klaus E
AU  - Andersen KE
AD  - Department of Dermatology, Odense University Hospital, 5000 Odense, Denmark. 
      kea@dou.dk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20030507
PL  - Germany
TA  - Int Arch Occup Environ Health
JT  - International archives of occupational and environmental health
JID - 7512134
SB  - IM
MH  - *Dermatitis, Allergic Contact/epidemiology/etiology/prevention & control
MH  - *Dermatitis, Occupational/diagnosis/epidemiology/etiology/prevention & control
MH  - Dose-Response Relationship, Immunologic
MH  - Humans
MH  - Occupational Exposure/adverse effects/analysis/prevention & control
MH  - Patch Tests
RF  - 28
EDAT- 2003/05/08 05:00
MHDA- 2004/01/10 05:00
CRDT- 2003/05/08 05:00
PHST- 2002/01/15 00:00 [received]
PHST- 2002/08/21 00:00 [accepted]
PHST- 2003/05/08 05:00 [pubmed]
PHST- 2004/01/10 05:00 [medline]
PHST- 2003/05/08 05:00 [entrez]
AID - 10.1007/s00420-002-0420-7 [doi]
PST - ppublish
SO  - Int Arch Occup Environ Health. 2003 Jun;76(5):347-50. doi: 
      10.1007/s00420-002-0420-7. Epub 2003 May 7.