PMID- 12735629
OWN - NLM
STAT- MEDLINE
DCOM- 20031204
LR  - 20191025
IS  - 0272-4340 (Print)
IS  - 0272-4340 (Linking)
VI  - 23
IP  - 2
DP  - 2003 Apr
TI  - NR2A but not NR2B N-methyl-D-aspartate receptor subunit is altered in the visual 
      cortex of BDNF-knock-out mice.
PG  - 165-74
AB  - 1. Aim of the present paper is to study the expression of N-Methyl-D-Aspartate 
      receptor (NMDAR) subunits NR2A and NR2B within mouse visual cortex. 2. To 
      investigate the influence of neurotrophic factor of NGF family (neurotrophins) on 
      NMDAR expression we used mutant mice carrying a deletion in the gene for 
      brain-derived neurotrophic factor (BDNF), a well-known neurotrophin expressed in 
      visual cortex. 3. Western blot and immunohistochemistry were performed at 
      postnatal day P12-14, P21-23, and adulthood showing that both subunits change 
      during postnatal development. 4. Absence of BDNF induced a reduction of NR2A 
      level. This effect was specific since the other subunit investigated, NR2B, was 
      not affected in mutant mice. 5. We conclude that endogenous BDNF modulates NMDAR 
      expression in the developing visual cortex.
FAU - Margottil, Elisa
AU  - Margottil E
AD  - Cognitive Neuroscience Sector, International School for Advanced Studies (SISSA), 
      via Beirut, Trieste, Italy.
FAU - Domenici, Luciano
AU  - Domenici L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NR2A NMDA receptor)
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*deficiency/genetics
MH  - Gene Expression Regulation/physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Receptors, N-Methyl-D-Aspartate/analysis/*biosynthesis/genetics
MH  - Visual Cortex/chemistry/*metabolism
EDAT- 2003/05/09 05:00
MHDA- 2003/12/05 05:00
CRDT- 2003/05/09 05:00
PHST- 2003/05/09 05:00 [pubmed]
PHST- 2003/12/05 05:00 [medline]
PHST- 2003/05/09 05:00 [entrez]
AID - 10.1023/a:1022945821455 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2003 Apr;23(2):165-74. doi: 10.1023/a:1022945821455.