PMID- 12735642
OWN - NLM
STAT- MEDLINE
DCOM- 20030916
LR  - 20190111
IS  - 0001-5555 (Print)
IS  - 0001-5555 (Linking)
VI  - 83
IP  - 2
DP  - 2003
TI  - Human herpes virus 6 encephalitis in allopurinol-induced hypersensitivity 
      syndrome.
PG  - 128-31
AB  - Hypersensitivity syndrome is one of the most severe forms of drug eruption, and 
      is characterized by a severe, potentially lethal, multiorgan involvement. 
      Recently, reactivation of human herpesvirus 6 (HHV-6) has been suggested to be 
      involved in this syndrome, although the exact role of HHV-6 remains elusive. In 
      addition to exanthem subitum, neurological illnesses, such as infantile febrile 
      illness without rash and encephalitis in immunocompromised patients have been 
      attributed to HHV-6. A 51-year-old man developed a generalized erythematous 
      eruption during treatment with allopurinol. Prednisolone improved his condition, 
      but after the dose of prednisolone was reduced neurological abnormalities such as 
      mental deterioration and positive meningeal signs developed. HHV-6 DNA in his 
      blood by PCR analysis was positive. Furthermore, we detected HHV-6 DNA in the 
      cerebrospinal fluid. The titers of anti-HHV-6-IgG increased during the course. 
      His neurological symptoms gradually improved and no neurological sequelae were 
      noted. Neurological abnormalities associated with hypersensitivity syndrome are 
      very rare. However, the detection of HHV-6 DNA in the cerebrospinal fluid 
      strongly indicates an involvement of reactivated HHV-6 in encephalitis.
FAU - Masaki, Taro
AU  - Masaki T
AD  - Division of Dermatology, Clinical Molecular Medicine, Faculty of Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Fukunaga, Atsushi
AU  - Fukunaga A
FAU - Tohyama, Mikiko
AU  - Tohyama M
FAU - Koda, Yoshiyuki
AU  - Koda Y
FAU - Okuda, Shiho
AU  - Okuda S
FAU - Maeda, Nobuya
AU  - Maeda N
FAU - Kanda, Fumio
AU  - Kanda F
FAU - Yasukawa, Masaki
AU  - Yasukawa M
FAU - Hashimoto, Koji
AU  - Hashimoto K
FAU - Horikawa, Tatsuya
AU  - Horikawa T
FAU - Ueda, Masato
AU  - Ueda M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Sweden
TA  - Acta Derm Venereol
JT  - Acta dermato-venereologica
JID - 0370310
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Gout Suppressants)
RN  - 63CZ7GJN5I (Allopurinol)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Allopurinol/*adverse effects
MH  - Anti-Inflammatory Agents/adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Drug Hypersensitivity/*complications/drug therapy/etiology
MH  - Encephalitis, Herpes Simplex/*complications
MH  - Gout Suppressants/*adverse effects
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prednisolone/adverse effects
MH  - Recurrence
EDAT- 2003/05/09 05:00
MHDA- 2003/09/17 05:00
CRDT- 2003/05/09 05:00
PHST- 2003/05/09 05:00 [pubmed]
PHST- 2003/09/17 05:00 [medline]
PHST- 2003/05/09 05:00 [entrez]
AID - 10.1080/00015550310007481 [doi]
PST - ppublish
SO  - Acta Derm Venereol. 2003;83(2):128-31. doi: 10.1080/00015550310007481.