PMID- 12735939
OWN - NLM
STAT- MEDLINE
DCOM- 20030730
LR  - 20190916
IS  - 0093-934X (Print)
IS  - 0093-934X (Linking)
VI  - 85
IP  - 2
DP  - 2003 May
TI  - Neural basis for sentence comprehension deficits in frontotemporal dementia.
PG  - 211-21
AB  - Many patients with frontotemporal dementia (FTD) have impaired sentence 
      comprehension. However, the pattern of comprehension difficulty appears to vary 
      depending on the clinical subgroup. The purpose of this study was to elucidate 
      the neural basis for these deficits in FTD. We studied patients with two 
      different presentations: Three patients with Progressive Non-Fluent Ahasia 
      (PNFA), and five non-aphasic patients with a dysexecutive and social impairment 
      (EXEC). The FTD patient subgroups were compared to a cohort of 11 healthy seniors 
      with intact sentence comprehension. We monitored regional cerebral activity with 
      blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) 
      while subjects read sentences featuring both a grammatically complex 
      object-relative center-embedded clause and a long linkage between the head noun 
      phrase (NP) and the gap where the NP is interpreted in the center-embedded 
      clause. Subjects decided whether the agent of the action is a male or a female. 
      Healthy seniors activated both ventral portions of inferior frontal cortex (vIFC) 
      and dorsal portions of IFC (dIFC) in the left hemisphere, often associated with 
      grammatical and working memory components of these sentences, respectively. PNFA 
      patients differed from healthy controls since they have reduced activation of 
      left vIFC, while EXEC patients have less recruitment of left dIFC. We conclude 
      that FTD subgroups have distinct patterns of sentence comprehension difficulty in 
      part because of selective interruptions of a large-scale neural network for 
      sentence processing.
FAU - Cooke, Ayanna
AU  - Cooke A
AD  - Department of Neurology-2 Gibson, University of Pennsylvania Medical Center, 3400 
      Spruce Street, Philadelphia, PA 19104-4283, USA.
FAU - DeVita, Christian
AU  - DeVita C
FAU - Gee, James
AU  - Gee J
FAU - Alsop, David
AU  - Alsop D
FAU - Detre, John
AU  - Detre J
FAU - Chen, Willis
AU  - Chen W
FAU - Grossman, Murray
AU  - Grossman M
LA  - eng
GR  - AG15116/AG/NIA NIH HHS/United States
GR  - AG17586/AG/NIA NIH HHS/United States
GR  - DC00237/DC/NIDCD NIH HHS/United States
GR  - NS35867/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Lang
JT  - Brain and language
JID - 7506220
SB  - IM
MH  - Aged
MH  - Aphasia, Broca/*diagnosis/physiopathology
MH  - Cognition Disorders/diagnosis
MH  - Dementia/*pathology
MH  - Female
MH  - Frontal Lobe/blood supply/*pathology/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Random Allocation
MH  - Severity of Illness Index
MH  - Speech Perception/*physiology
MH  - Temporal Lobe/blood supply/*pathology/physiopathology
EDAT- 2003/05/09 05:00
MHDA- 2003/07/31 05:00
CRDT- 2003/05/09 05:00
PHST- 2003/05/09 05:00 [pubmed]
PHST- 2003/07/31 05:00 [medline]
PHST- 2003/05/09 05:00 [entrez]
AID - S0093934X0200562X [pii]
AID - 10.1016/s0093-934x(02)00562-x [doi]
PST - ppublish
SO  - Brain Lang. 2003 May;85(2):211-21. doi: 10.1016/s0093-934x(02)00562-x.