PMID- 12736054
OWN - NLM
STAT- MEDLINE
DCOM- 20040121
LR  - 20190922
IS  - 1386-1425 (Print)
IS  - 1386-1425 (Linking)
VI  - 59
IP  - 8
DP  - 2003 Jun
TI  - Effect of aluminum (III) on the conversion of dopachrome in the melanin synthesis 
      pathway.
PG  - 1689-96
AB  - The effect of aluminum ions on the kinetics and mode of the conversion of 
      dopachrome (DC) in acidic environment has been studied using UV-Vis 
      spectrophotometric and cyclic voltammetric methods. The DC conversion step is an 
      important reaction in melanogenesis. Aluminum ions catalyze greatly the 
      decarboxylative transformation of DC to give 5,6-dihydroxyindole (DHI) rather 
      than 5,6-dihydroxyindole-2-carboxylic acid (DHICA) at pH 5.5, which enhance the 
      ratio of formation DHI/DHICA in melanin synthesis pathway. The kinetics of DC 
      conversion catalyzed by aluminum ions is dependent on the concentration of DC and 
      aluminum ions. These results provide evidence that aluminum ions could play a 
      role in the synthesis of melanin pathway in acidic condition through catalyzing 
      the DC decarboxylative transformation to yield DHI and influence the melanin 
      structure and properties.
FAU - Di, Junwei
AU  - Di J
AD  - Department of Chemistry, Nanjing University, Nanjing 210093, People's Republic of 
      China.
FAU - Bi, Shuping
AU  - Bi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Spectrochim Acta A Mol Biomol Spectrosc
JT  - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
JID - 9602533
RN  - 0 (Indolequinones)
RN  - 0 (Indoles)
RN  - 0 (Ions)
RN  - 0 (Melanins)
RN  - 3571-34-4 (dopachrome)
RN  - CPD4NFA903 (Aluminum)
RN  - Z3OC8499KG (5,6-dihydroxyindole)
SB  - IM
MH  - Aluminum/*chemistry
MH  - Hydrogen-Ion Concentration
MH  - Indolequinones/*chemistry
MH  - Indoles/chemistry
MH  - Ions
MH  - Kinetics
MH  - Melanins/*biosynthesis
MH  - Models, Chemical
MH  - Oxidative Stress
MH  - Spectrophotometry/*methods
MH  - Temperature
MH  - Time Factors
MH  - Ultraviolet Rays
EDAT- 2003/05/09 05:00
MHDA- 2004/01/22 05:00
CRDT- 2003/05/09 05:00
PHST- 2003/05/09 05:00 [pubmed]
PHST- 2004/01/22 05:00 [medline]
PHST- 2003/05/09 05:00 [entrez]
AID - S1386142502004031 [pii]
AID - 10.1016/s1386-1425(02)00403-1 [doi]
PST - ppublish
SO  - Spectrochim Acta A Mol Biomol Spectrosc. 2003 Jun;59(8):1689-96. doi: 
      10.1016/s1386-1425(02)00403-1.