PMID- 12736472
OWN - NLM
STAT- MEDLINE
DCOM- 20031217
LR  - 20190819
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 67
IP  - 5
DP  - 2003 May
TI  - Hemodynamic and hormonal effects of beraprost sodium, an orally active 
      prostacyclin analogue, in patients with secondary precapillary pulmonary 
      hypertension.
PG  - 375-8
AB  - Earlier studies have shown that administration of beraprost sodium (BPS), an 
      orally active prostacyclin analogue, improves hemodynamics in patients with 
      primary pulmonary hypertension (PH), but it is not known whether BPS has 
      beneficial effects in secondary precapillary PH. The present study investigated 
      the hemodynamic and hormonal parameters of 18 patients with secondary 
      precapillary PH (8 patients with chronic thromboembolic PH, 7 with collagen 
      vascular disease, and 3 with residual PH after surgery for atrial septal defect). 
      Hemodynamics were repeatedly measured by right heart catheterization. Treatment 
      with BPS improved New York Heart Association (NYHA) functional class in 10 of the 
      18 patients and significantly decreased pulmonary vascular resistance by 17% 
      (12.9+/-1.1 to 10.7+/-1.2 Wood units, p<0.01). Circulating brain natriuretic 
      peptide and uric acid significantly decreased from 246+/-61 to 215+/-65 pg/ml and 
      from 6.5+/-0.6 to 5.3+/-0.3 mg/dl, respectively. In summary, BPS therapy improved 
      NYHA functional class, hemodynamics, and hormonal parameters in patients with 
      secondary precapillary PH. Thus, oral administration of BPS may be a new 
      therapeutic strategy for the treatment of secondary precapillary PH.
FAU - Ono, Fumiaki
AU  - Ono F
AD  - Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan.
FAU - Nagaya, Noritoshi
AU  - Nagaya N
FAU - Kyotani, Shingo
AU  - Kyotani S
FAU - Oya, Hideo
AU  - Oya H
FAU - Nakanishi, Norifumi
AU  - Nakanishi N
FAU - Miyatake, Kunio
AU  - Miyatake K
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Vasodilator Agents)
RN  - 35E3NJJ4O6 (beraprost)
RN  - DCR9Z582X0 (Epoprostenol)
SB  - IM
MH  - Administration, Oral
MH  - Capillaries/drug effects/*physiopathology
MH  - Epoprostenol/administration & dosage/adverse effects/*analogs & 
      derivatives/*therapeutic use
MH  - Female
MH  - Hemodynamics/drug effects/*physiology
MH  - Humans
MH  - Hypertension, Pulmonary/*drug therapy/etiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Thromboembolism/complications
MH  - Vascular Diseases/complications
MH  - Vasodilator Agents/administration & dosage/adverse effects/*therapeutic use
EDAT- 2003/05/09 05:00
MHDA- 2003/12/18 05:00
CRDT- 2003/05/09 05:00
PHST- 2003/05/09 05:00 [pubmed]
PHST- 2003/12/18 05:00 [medline]
PHST- 2003/05/09 05:00 [entrez]
AID - 10.1253/circj.67.375 [doi]
PST - ppublish
SO  - Circ J. 2003 May;67(5):375-8. doi: 10.1253/circj.67.375.