PMID- 12736485
OWN - NLM
STAT- MEDLINE
DCOM- 20031217
LR  - 20190819
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 67
IP  - 5
DP  - 2003 May
TI  - Administration of atrial natriuretic peptide attenuates reperfusion phenomena and 
      preserves left ventricular regional wall motion after direct coronary angioplasty 
      for acute myocardial infarction.
PG  - 443-8
AB  - To evaluate the effects of synthetic human atrial natriuretic peptide (hANP) on 
      myocardial reperfusion injury and left ventricular remodeling, 19 patients within 
      12 h of a first attack of anterior myocardial infarction (AMI) underwent 
      intracoronary injection of 25 microg of hANP immediately after coronary 
      angioplasty, combined with intravenous infusion of 0.025 microg x kg(-1) x 
      min(-1) of hANP initiated on admission for 1 week (hANP group); 18 similar 
      patients had saline administered (control group). The incidences of premature 
      ventricular contraction, ventricular tachycardia and/or fibrillation in the hANP 
      group were significantly less than in the control group after coronary 
      angioplasty. Left ventricular ejection fraction was significantly greater and 
      left ventricular end-diastolic volume index was significantly smaller 6 months 
      after coronary angioplasty. Left ventricular regional wall motion of the 
      infarcted segments significantly increased. Thus, hANP remarkably suppressed 
      reperfusion phenomena and preserved left ventricular function through improvement 
      of regional wall motion of the infarcted segments after coronary angioplasty.
FAU - Kuga, Hideyo
AU  - Kuga H
AD  - Department of Cardiology and Pneumology, Dokkyo University School of Medicine, 
      Tochigi, Japan.
FAU - Ogawa, Kenichi
AU  - Ogawa K
FAU - Oida, Akitugu
AU  - Oida A
FAU - Taguchi, Isao
AU  - Taguchi I
FAU - Nakatsugawa, Masatoshi
AU  - Nakatsugawa M
FAU - Hoshi, Toshiyasu
AU  - Hoshi T
FAU - Sugimura, Hiroyasu
AU  - Sugimura H
FAU - Abe, Shichirou
AU  - Abe S
FAU - Kaneko, Noboru
AU  - Kaneko N
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - *Angioplasty, Balloon, Coronary/adverse effects
MH  - Atrial Natriuretic Factor/*therapeutic use
MH  - Blood Pressure/drug effects
MH  - Coronary Circulation/drug effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/drug effects
MH  - Myocardial Infarction/*therapy
MH  - Myocardial Reperfusion Injury/*prevention & control
MH  - Ventricular Fibrillation/etiology/physiopathology
MH  - Ventricular Function, Left/drug effects/*physiology
EDAT- 2003/05/09 05:00
MHDA- 2003/12/18 05:00
CRDT- 2003/05/09 05:00
PHST- 2003/05/09 05:00 [pubmed]
PHST- 2003/12/18 05:00 [medline]
PHST- 2003/05/09 05:00 [entrez]
AID - 10.1253/circj.67.443 [doi]
PST - ppublish
SO  - Circ J. 2003 May;67(5):443-8. doi: 10.1253/circj.67.443.