PMID- 12738784
OWN - NLM
STAT- MEDLINE
DCOM- 20030827
LR  - 20210206
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 278
IP  - 29
DP  - 2003 Jul 18
TI  - Transcriptional activation of the human brain-derived neurotrophic factor gene 
      promoter III by dopamine signaling in NT2/N neurons.
PG  - 26401-9
AB  - We have identified a functional cAMP-response element (CRE) in the human 
      brain-derived neurotrophic factor (BDNF) gene promoter III and established that 
      it participated in the modulation of BDNF expression in NT2/N neurons via 
      downstream signaling from the D1 class of dopamine (DA) receptors. The 
      up-regulation of BDNF expression, in turn, produced neuroprotective signals 
      through receptor tyrosine kinase B (TrkB) and promoted cell survival under the 
      conditions of oxygen and glucose deprivation. To our knowledge this is the first 
      evidence showing the presence of a functional CRE in the human BDNF gene and the 
      role of DA signaling in establishing transcriptional competence of CRE in 
      post-mitotic NT2/N neurons. This ability of DA to regulate the expression of the 
      BDNF survival factor has a profound significance for the nigrostriatal pathway, 
      because it indicates the existence of a feedback loop between the neutrophin, 
      which promotes both the maturation and survival of dopaminergic neurons, and the 
      neurotransmitter, which the mature neurons ultimately produce and release.
FAU - Fang, Hung
AU  - Fang H
AD  - Neurobiology Program, Institute for Biological Sciences, National Research 
      Council of Canada, Ottawa, Ontario K1A 0R6, Canada. hung.fang@nrc.ca
FAU - Chartier, Joanne
AU  - Chartier J
FAU - Sodja, Caroline
AU  - Sodja C
FAU - Desbois, Angele
AU  - Desbois A
FAU - Ribecco-Lutkiewicz, Maria
AU  - Ribecco-Lutkiewicz M
FAU - Walker, P Roy
AU  - Walker PR
FAU - Sikorska, Marianna
AU  - Sikorska M
LA  - eng
PT  - Journal Article
DEP - 20030508
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Receptors, Dopamine D1)
RN  - 63X7MBT2LQ (Bucladesine)
RN  - 9007-49-2 (DNA)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Bucladesine/pharmacology
MH  - Cell Differentiation
MH  - Cell Line
MH  - Cell Survival
MH  - Cyclic AMP/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - DNA/genetics/metabolism
MH  - Dopamine/*metabolism
MH  - Humans
MH  - Molecular Sequence Data
MH  - Neurons/cytology/drug effects/metabolism
MH  - *Promoter Regions, Genetic
MH  - Rats
MH  - Receptor, trkB/metabolism
MH  - Receptors, Dopamine D1/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
MH  - Signal Transduction
MH  - Transcriptional Activation/drug effects
EDAT- 2003/05/10 05:00
MHDA- 2003/08/28 05:00
CRDT- 2003/05/10 05:00
PHST- 2003/05/10 05:00 [pubmed]
PHST- 2003/08/28 05:00 [medline]
PHST- 2003/05/10 05:00 [entrez]
AID - S0021-9258(20)84588-8 [pii]
AID - 10.1074/jbc.M211539200 [doi]
PST - ppublish
SO  - J Biol Chem. 2003 Jul 18;278(29):26401-9. doi: 10.1074/jbc.M211539200. Epub 2003 
      May 8.