PMID- 12739041
OWN - NLM
STAT- MEDLINE
DCOM- 20040122
LR  - 20190816
IS  - 0172-8172 (Print)
IS  - 0172-8172 (Linking)
VI  - 23
IP  - 3
DP  - 2003 May
TI  - Polymorphism of the Duffy erythrocyte chemokine receptor in Italian patients with 
      Behcet's disease.
PG  - 116-20
AB  - This study examined the hypothesis that the polymorphism of Duffy antigen 
      receptor for chemokines (DARC) predisposes to and/or influences the clinical 
      manifestations of Behcet's disease. The serum levels of IL-8 and monocyte 
      chemotactic peptide (MCP)-1, two DARC-binding chemokines, were investigated and 
      related to this polymorphism. Twenty-eight patients with Behcet's disease and 30 
      healthy blood donors were included in the study. No null phenotypes were found 
      among the patients studied, and the frequencies of the other phenotypes 
      (Fy((a+b-)), Fy((a+b+)), and Fy((a-b+))) did not significantly differ from those 
      found in the blood donor group or reported in the general Caucasian population. 
      No difference was found between the single phenotypes in terms of IL-8 and MCP-1 
      serum levels, and no relevant association between the clinical characteristics, 
      Behcet's disease-associated human leukocyte antigen (HLA)-B51, and single 
      phenotypes was observed. This investigation indicates that DARC is not a genetic 
      trait significantly associated with or predisposing to Behcet's disease, at least 
      in Caucasian Italians. However, the role of this polymorphism in the development 
      and in the clinical course of the disease awaits further investigation.
FAU - Pittoni, V
AU  - Pittoni V
AD  - Division of Rheumatology, University of Rome La Sapienza, Policlinico Umberto I, 
      00161, Rome, Italy.
FAU - Vaglio, S
AU  - Vaglio S
FAU - Magrini, L
AU  - Magrini L
FAU - Accorinti, M
AU  - Accorinti M
FAU - Pivetti-Pezzi, P
AU  - Pivetti-Pezzi P
FAU - Girelli, G
AU  - Girelli G
FAU - Valesini, G
AU  - Valesini G
LA  - eng
PT  - Journal Article
DEP - 20030118
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (ACKR1 protein, human)
RN  - 0 (Antigens, Protozoan)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Duffy Blood-Group System)
RN  - 0 (Duffy antigen binding protein, Plasmodium)
RN  - 0 (Genetic Markers)
RN  - 0 (Interleukin-8)
RN  - 0 (Protozoan Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Adult
MH  - Antigens, Protozoan/*genetics/metabolism
MH  - Behcet Syndrome/blood/epidemiology/*genetics
MH  - Chemokine CCL2/blood
MH  - Duffy Blood-Group System
MH  - Erythrocytes/metabolism
MH  - Female
MH  - Genetic Markers
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-8/blood
MH  - Italy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - Protozoan Proteins/*genetics/metabolism
MH  - Receptors, Cell Surface/*genetics/metabolism
MH  - Receptors, Chemokine/genetics/metabolism
EDAT- 2003/05/10 05:00
MHDA- 2004/01/24 05:00
CRDT- 2003/05/10 05:00
PHST- 2002/04/27 00:00 [received]
PHST- 2002/09/29 00:00 [accepted]
PHST- 2003/05/10 05:00 [pubmed]
PHST- 2004/01/24 05:00 [medline]
PHST- 2003/05/10 05:00 [entrez]
AID - 10.1007/s00296-002-0269-9 [doi]
PST - ppublish
SO  - Rheumatol Int. 2003 May;23(3):116-20. doi: 10.1007/s00296-002-0269-9. Epub 2003 
      Jan 18.