PMID- 12742638
OWN - NLM
STAT- MEDLINE
DCOM- 20030722
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 974
IP  - 1-2
DP  - 2003 Jun 6
TI  - Progesterone attenuates the effect of the 5-HT1A receptor agonist, 8-OH-DPAT, and 
      of mild restraint on lordosis behavior.
PG  - 202-11
AB  - Ovariectomized, hormone-primed rats were used to test the hypothesis that 
      progesterone treatment attenuated the effects of the 5-HT(1A) receptor agonist, 
      (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), on female rat lordosis 
      behavior. Based upon prior evidence that prepriming with estradiol benzoate (EB) 
      reduced the ability of 8-OH-DPAT to inhibit lordosis behavior, rats were 
      preprimed with 10 microg EB 7 days before a second priming with 10 microg EB 
      followed 48 h later with 500 microg progesterone or vehicle. Independent of the 
      presence of progesterone, prepriming with EB attenuated the lordosis-inhibiting 
      effects of systemic treatment with 8-OH-DPAT. However, progesterone also reduced 
      the effects of 8-OH-DPAT and this effect was also seen in females primed only 
      once with EB. In contrast, progesterone was relatively ineffective in attenuating 
      the effects of bilateral infusion with 8-OH-DPAT into the ventromedial nucleus of 
      the hypothalamus (VMN). The failure of progesterone to substantially reduce the 
      effects of VMN infusion with 8-OH-DPAT contrasts with prior studies in which 
      estrogen's protective action against the drug did include the VMN. Thus, while 
      both estrogen and progesterone reduce the lordosis-inhibiting effect of 
      8-OH-DPAT, the mechanisms responsible for the effects of the two gonadal hormones 
      may be different. Priming with progesterone also prevented the effects of 5 min 
      of restraint. When rats were hormonally primed with EB and oil, rats showed a 
      transient, but significant, decline in lordosis behavior 5 and 10 min after 
      restraint. Rats primed with EB and progesterone were unaffected by the restraint. 
      These results are discussed in terms of their implications for the role of 
      progesterone in altering the 5-HT(1A) receptor modulation of lordosis behavior.
FAU - Truitt, William
AU  - Truitt W
AD  - Department of Biology, Texas Woman's University, PO Box 425799, Denton 
      76204-5799, USA.
FAU - Harrison, Lance
AU  - Harrison L
FAU - Guptarak, Jutatip
AU  - Guptarak J
FAU - White, Stacy
AU  - White S
FAU - Hiegel, Cindy
AU  - Hiegel C
FAU - Uphouse, Lynda
AU  - Uphouse L
LA  - eng
GR  - GM55380/GM/NIGMS NIH HHS/United States
GR  - HD28419/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Receptors, Serotonin, 5-HT1)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/*antagonists & inhibitors/*pharmacology
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Estrogens/pharmacology
MH  - Female
MH  - Ovariectomy
MH  - Posture/*physiology
MH  - Progesterone/*pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptors, Serotonin/*drug effects
MH  - Receptors, Serotonin, 5-HT1
MH  - Restraint, Physical
MH  - Serotonin Receptor Agonists/*pharmacology
MH  - Sexual Behavior, Animal/*drug effects
MH  - Stress, Psychological/*psychology
EDAT- 2003/05/14 05:00
MHDA- 2003/07/23 05:00
CRDT- 2003/05/14 05:00
PHST- 2003/05/14 05:00 [pubmed]
PHST- 2003/07/23 05:00 [medline]
PHST- 2003/05/14 05:00 [entrez]
AID - S0006899303025812 [pii]
AID - 10.1016/s0006-8993(03)02581-2 [doi]
PST - ppublish
SO  - Brain Res. 2003 Jun 6;974(1-2):202-11. doi: 10.1016/s0006-8993(03)02581-2.