PMID- 12742653
OWN - NLM
STAT- MEDLINE
DCOM- 20031106
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 138
IP  - 1-2
DP  - 2003 May
TI  - Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain 
      and maternal-fetal unit of the rat.
PG  - 49-55
AB  - Maternal infection during pregnancy is associated with increased risk for 
      neurodevelopmental disorders. Lipopolysaccharide (LPS) or saline was administered 
      to rats to model maternal infection, and levels of brain-derived neurotrophic 
      factor (BDNF) and nerve growth factor (NGF) in maternal plasma, placenta, 
      amniotic fluid, fetal liver/spleen, fetal brain, and cerebral cortex after birth 
      were determined by ELISA or semiquantitative Western blot analysis. BDNF 
      expression was significantly increased in the fetal brain (p=0.039); NGF 
      expression was significantly increased in neonatal cortex (p=0.0009). 
      Neurotrophic factor expression was also altered in other tissues of the 
      maternal-fetal unit. Abnormal expression of neurotrophic factors represents a 
      potential mechanism through which maternal infection increases risk for 
      neurodevelopmental disorders.
FAU - Gilmore, John H
AU  - Gilmore JH
AD  - Department of Psychiatry, CB #7160, University of North Carolina at Chapel Hill, 
      Chapel Hill, NC 27599-7160, USA. jgilmore@med.unc.edu
FAU - Jarskog, L Fredrik
AU  - Jarskog LF
FAU - Vadlamudi, Swarooparani
AU  - Vadlamudi S
LA  - eng
GR  - MH60352/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/embryology/immunology/*metabolism
MH  - Brain-Derived Neurotrophic Factor/antagonists & inhibitors/*biosynthesis/blood
MH  - Escherichia coli Infections/blood/immunology/*metabolism
MH  - Female
MH  - Fetus
MH  - Injections, Intraperitoneal
MH  - Lipopolysaccharides/toxicity
MH  - Liver/embryology/immunology/metabolism
MH  - Male
MH  - Maternal-Fetal Exchange/*immunology
MH  - Nerve Growth Factor/*biosynthesis
MH  - Placenta/immunology/metabolism
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/blood/immunology/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spleen/embryology/immunology/metabolism
MH  - Tumor Necrosis Factor-alpha/biosynthesis
MH  - Up-Regulation/immunology
EDAT- 2003/05/14 05:00
MHDA- 2003/11/07 05:00
CRDT- 2003/05/14 05:00
PHST- 2003/05/14 05:00 [pubmed]
PHST- 2003/11/07 05:00 [medline]
PHST- 2003/05/14 05:00 [entrez]
AID - S016557280300095X [pii]
AID - 10.1016/s0165-5728(03)00095-x [doi]
PST - ppublish
SO  - J Neuroimmunol. 2003 May;138(1-2):49-55. doi: 10.1016/s0165-5728(03)00095-x.