PMID- 12742659
OWN - NLM
STAT- MEDLINE
DCOM- 20031106
LR  - 20220321
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 138
IP  - 1-2
DP  - 2003 May
TI  - Basal serum levels and reactivity of nerve growth factor and brain-derived 
      neurotrophic factor to standardized acute exercise in multiple sclerosis and 
      controls.
PG  - 99-105
AB  - Neurotrophins like brain-derived neurotrophic factor (BDNF) and nerve growth 
      factor (NGF) are thought to play an important role in neuronal repair and 
      plasticity. Recent experimental evidence suggests neuroprotective effects of 
      these proteins in multiple sclerosis (MS). We investigated the response of serum 
      NGF and BDNF concentrations to standardized acute exercise in MS patients and 
      controls. Basal NGF levels were significantly elevated in MS. Thirty minutes of 
      moderate exercise significantly induced BDNF production in MS patients and 
      controls, but no differential effects were seen. We conclude that moderate 
      exercise can be used to induce neutrophin production in humans. This may mediate 
      beneficial effects of physical exercise in MS reported recently.
FAU - Gold, Stefan M
AU  - Gold SM
AD  - Department of Neurology, University Hospital Hamburg-Eppendorf, Martinistrasse 
      52, 20246, Hamburg, Germany. gold@uke.uni-hamburg.de
FAU - Schulz, Karl-Heinz
AU  - Schulz KH
FAU - Hartmann, Sten
AU  - Hartmann S
FAU - Mladek, Mila
AU  - Mladek M
FAU - Lang, Undine E
AU  - Lang UE
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Reer, Rudiger
AU  - Reer R
FAU - Braumann, Klaus-Michael
AU  - Braumann KM
FAU - Heesen, Christoph
AU  - Heesen C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - *Exercise Test/standards/statistics & numerical data
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Lactic Acid/blood
MH  - Male
MH  - Multiple Sclerosis/*blood/*physiopathology
MH  - Nerve Growth Factor/*blood
MH  - Sex Factors
MH  - Time Factors
EDAT- 2003/05/14 05:00
MHDA- 2003/11/07 05:00
CRDT- 2003/05/14 05:00
PHST- 2003/05/14 05:00 [pubmed]
PHST- 2003/11/07 05:00 [medline]
PHST- 2003/05/14 05:00 [entrez]
AID - S0165572803001218 [pii]
AID - 10.1016/s0165-5728(03)00121-8 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2003 May;138(1-2):99-105. doi: 10.1016/s0165-5728(03)00121-8.