PMID- 12742741
OWN - NLM
STAT- MEDLINE
DCOM- 20030702
LR  - 20191107
IS  - 0969-9961 (Print)
IS  - 0969-9961 (Linking)
VI  - 12
IP  - 3
DP  - 2003 Apr
TI  - Enhanced long-term potentiation in the hippocampus of rats expressing mutant 
      presenillin-1 is age related.
PG  - 212-24
AB  - Electrophysiological recordings were made from Fischer rats engineered to express 
      the human presenilin 1 gene carrying the M146V mutation. Extracellular recordings 
      of field excitatory post-synaptic potential (EPSPs) were made to investigate EPSP 
      properties, paired pulse responses, posttetanic potentiation, and long-term 
      potentiation in the stratum radiatum and dentate gyrus of hippocampal slices 
      maintained in vitro. Transgenic rats aged approximately 6 months showed no 
      differences from their wild-type littermates in any of these properties. However, 
      at 18 months, long-term potentiation in the CA1 was facilitated in the transgenic 
      rats with a different pattern of synaptic enhancement. No changes were observed 
      in paired pulse facilitation (PPF) or post-tetanic potentiation (PPT) and no 
      changes were seen in the dentate gyrus. Field potential amplitudes were 
      significantly greater and PPF was enhanced in the CA1 of all older rats. 
      Intracellular recordings from CA1 pyramidal cells of the older group of rats 
      revealed no differences in the passive or active membrane properties of cells in 
      the two groups, but intracellularly recorded EPSPs were significantly longer.
FAU - Pybus, Ruth
AU  - Pybus R
AD  - Biomedical Sciences, University Medical School, George Square, Edinburgh EH8 9XD, 
      UK.
FAU - Barnard, Eleanor
AU  - Barnard E
FAU - Estibeiro, Peter
AU  - Estibeiro P
FAU - Mullins, John
AU  - Mullins J
FAU - MacLeod, Nikki
AU  - MacLeod N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Membrane Proteins)
RN  - 0 (PSEN1 protein, human)
RN  - 0 (Presenilin-1)
SB  - IM
MH  - Aging/*physiology
MH  - Alzheimer Disease/*genetics/physiopathology
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Brain/pathology
MH  - Electrophysiology
MH  - Excitatory Postsynaptic Potentials/physiology
MH  - Hippocampus/physiology/*physiopathology
MH  - Humans
MH  - Long-Term Potentiation/*genetics
MH  - Membrane Potentials/physiology
MH  - Membrane Proteins/*genetics
MH  - Models, Animal
MH  - *Mutation
MH  - Organ Culture Techniques
MH  - Patch-Clamp Techniques
MH  - Presenilin-1
MH  - Rats
MH  - Rats, Inbred F344
EDAT- 2003/05/14 05:00
MHDA- 2003/07/03 05:00
CRDT- 2003/05/14 05:00
PHST- 2003/05/14 05:00 [pubmed]
PHST- 2003/07/03 05:00 [medline]
PHST- 2003/05/14 05:00 [entrez]
AID - S0969996103000160 [pii]
AID - 10.1016/s0969-9961(03)00016-0 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2003 Apr;12(3):212-24. doi: 10.1016/s0969-9961(03)00016-0.