PMID- 12745086
OWN - NLM
STAT- MEDLINE
DCOM- 20030717
LR  - 20220227
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 305
IP  - 2
DP  - 2003 May 30
TI  - Monocyte chemoattractant protein-1 induces scavenger receptor expression and 
      monocyte differentiation into foam cells.
PG  - 380-5
AB  - Accumulation of monocytes and the entrapment of oxidized-low-density lipoprotein 
      (ox-LDL) in monocytes are important in the differentiation into "foam" 
      macrophages and the pathogenesis of atherosclerosis. We investigated the role of 
      monocyte chemoattractant protein-1 (MCP-1) in the expression of scavenger 
      receptor (SCR) by using resting monocytes prepared by counterflow centrifugal 
      elutriation. Our results showed that: (1) MCP-1 increased the expression of CD36 
      SCR by flow cytometric analysis. (2) MCP-1 increased incorporation of 
      125I-labeled ox-LDL and oil red O staining. (3) MCP-1 and ox-LDL enhanced in 
      vitro transendothelial monocyte migration. (4) These functions were mediated at 
      least in part via extracellular signal-regulated kinase (ERK) pathway. (5) MCP-1 
      and ox-LDL did not induce monocyte proliferation. Our results imply that MCP-1 is 
      involved in the inflammatory process of atherosclerosis through the induction of 
      SCR expression via the ERK pathway and differentiation of monocytes into foam 
      macrophages, as well as induction of monocyte migration.
FAU - Tabata, Takahiro
AU  - Tabata T
AD  - First Department of Internal Medicine, University of Occupational and 
      Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi, Kitakyushu, 
      807-8555, Japan.
FAU - Mine, Shinichiro
AU  - Mine S
FAU - Kawahara, Chie
AU  - Kawahara C
FAU - Okada, Yosuke
AU  - Okada Y
FAU - Tanaka, Yoshiya
AU  - Tanaka Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (CD36 Antigens)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Lipoprotein)
RN  - 0 (Receptors, Scavenger)
RN  - 0 (Scarb1 protein, mouse)
RN  - 0 (Scavenger Receptors, Class B)
RN  - 0 (oxidized low density lipoprotein)
SB  - IM
MH  - CD36 Antigens/*biosynthesis
MH  - Cell Differentiation
MH  - Cell Division
MH  - Cells, Cultured
MH  - Chemokine CCL2/*pharmacology
MH  - Chemotaxis, Leukocyte
MH  - Enzyme Inhibitors/pharmacology
MH  - Foam Cells/*cytology
MH  - Humans
MH  - Lipoproteins, LDL/metabolism/pharmacology
MH  - MAP Kinase Signaling System/drug effects
MH  - *Membrane Proteins
MH  - Monocytes/drug effects/*metabolism/*physiology
MH  - Receptors, Immunologic/*biosynthesis
MH  - *Receptors, Lipoprotein
MH  - Receptors, Scavenger
MH  - Scavenger Receptors, Class B
EDAT- 2003/05/15 05:00
MHDA- 2003/07/18 05:00
CRDT- 2003/05/15 05:00
PHST- 2003/05/15 05:00 [pubmed]
PHST- 2003/07/18 05:00 [medline]
PHST- 2003/05/15 05:00 [entrez]
AID - S0006291X0300771X [pii]
AID - 10.1016/s0006-291x(03)00771-x [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2003 May 30;305(2):380-5. doi: 
      10.1016/s0006-291x(03)00771-x.