PMID- 12745459
OWN - NLM
STAT- MEDLINE
DCOM- 20030729
LR  - 20171116
IS  - 0031-3025 (Print)
IS  - 0031-3025 (Linking)
VI  - 35
IP  - 2
DP  - 2003 Apr
TI  - CD44s expression correlated with the International Neuroblastoma Pathology 
      Classification (Shimada system) for neuroblastic tumours.
PG  - 125-9
AB  - AIM: CD44 is a cell adhesion molecule that plays an important role in the cascade 
      of metastasis and progression of human malignant tumours. A large family of 
      variants or isoforms, generated by alternative splicing of a single gene, has 
      been reported to be involved in the malignant process by conferring metastatic 
      potential to non-metastatic cells. The objective of this study was to compare the 
      expression of CD44 standard molecule with the International Neuroblastoma 
      Pathology Classification (INPC) for neuroblastic tumours, a histological grading 
      system based on the Shimada system for predicting the clinical outcome in 
      neuroblastic tumours. METHODS: Paraffin blocks of primary neuroblastic tumour 
      were graded according to the INPC system into favourable and unfavourable 
      histological types. Tumour tissues were then analysed with immunostaining using 
      monoclonal antibodies against the CD44 epitope. RESULTS: In this retrospective 
      study, 32 cases of primary neuroblastic tumour were collected. Based on the INPC 
      system, 13 cases (40.6%) had a favourable histology while 19 cases (59.4%) were 
      of unfavourable histology. CD44 standard (CD44s) expression was detected in 69.2% 
      of neuroblastic tumours with favourable histological type while 89.5% of tumours 
      with unfavourable histological type did not express CD44s staining. 
      Statistically, there was significant correlation between morphological grading of 
      neuroblastic tumours based on the INPC and the presence of CD44 staining 
      (Fisher's exact test, P<0.05). CONCLUSION: This study shows that there is a 
      significant correlation between CD44s expression and tumour histology based on 
      the INPC in which CD44s non-expression is correlated with an unfavourable 
      histological type and the expression of CD44s with a favourable type. Therefore, 
      the analysis of CD44s expression should be recommended as an additional 
      biological marker in the initial routine staging of the disease.
FAU - Munchar, M J Julia
AU  - Munchar MJ
AD  - Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 
      Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia. 
      julia@mail.hukm.ukm.my
FAU - Sharifah, N A
AU  - Sharifah NA
FAU - Jamal, R
AU  - Jamal R
FAU - Looi, L M
AU  - Looi LM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pathology
JT  - Pathology
JID - 0175411
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - Antigens, Neoplasm/*metabolism
MH  - Child
MH  - Child, Preschool
MH  - Ganglioneuroma/metabolism/pathology
MH  - Humans
MH  - Hyaluronan Receptors/*metabolism
MH  - Immunoenzyme Techniques
MH  - Infant
MH  - Neuroblastoma/classification/*metabolism/pathology
MH  - Prognosis
MH  - Protein Isoforms/metabolism
MH  - Retrospective Studies
EDAT- 2003/05/15 05:00
MHDA- 2003/07/30 05:00
CRDT- 2003/05/15 05:00
PHST- 2003/05/15 05:00 [pubmed]
PHST- 2003/07/30 05:00 [medline]
PHST- 2003/05/15 05:00 [entrez]
AID - 3W44EA0BTTUFMRLJ [pii]
PST - ppublish
SO  - Pathology. 2003 Apr;35(2):125-9.