PMID- 12747008
OWN - NLM
STAT- MEDLINE
DCOM- 20030804
LR  - 20180608
IS  - 0895-3988 (Print)
IS  - 0895-3988 (Linking)
VI  - 16
IP  - 1
DP  - 2003 Mar
TI  - 3,4-methylenedioxymethamphetamine (MDMA) abuse markedly inhibits 
      acetylcholinesterase activity and induces severe oxidative damage and 
      liperoxidative damage.
PG  - 53-61
AB  - OBJECTIVE: To investigate whether 3,4-methylenedioxymethamphetamine (MDMA) abuse 
      produces another neurotoxicity which may significantly inhibit the 
      acetylcholinesterase activity and result in severe oxidative damage and 
      liperoxidative damage to MDMA abusers. METHODS: 120 MDMA abusers (MA) and 120 
      healthy volunteers (HV) were enrolled in an independent sample control design, in 
      which the levels of lipoperoxide (LPO) in plasma and erythrocytes as well as the 
      activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase 
      (GPX) and acetylcholinesterase (AChE) in erythrocytes were determined by 
      spectrophotometric methods. RESULTS: Compared with the average values of 
      biochemical parameters in the HV group, those of LPO in plasma and erythrocytes 
      in the MA group were significantly increased (P < 0.0001), while those of SOD, 
      CAT, GPX and AChE in erythrocytes in the MA group were significantly decreased (P 
      < 0.0001). The Pearson product-moment correlation analysis between the values of 
      AChE and biochemical parameters in 120 MDMA abusers showed that significant 
      linear negative correlation was present between the activity of AChE and the 
      levels of LPO in plasma and erythrocytes (P < 0.0005-0.0001), while significant 
      linear positive correlation was observed between the activity of AchE and the 
      activities of SOD, CAT and GPX (P < 0.0001). The reliability analysis for the 
      above biochemical parameters reflecting oxidative and lipoperoxidative damages in 
      MDMA abusers suggested that the reliability coefficient (alpha) was 0.8124, and 
      that the standardized item alpha was 0.9453. CONCLUSION: The findings in the 
      present study suggest that MDMA abuse can induce another neurotoxicity that 
      significantly inhibits acetylcholinesterase activity and aggravates a series of 
      free radical chain reactions and oxidative stress in the bodies of MDMA abusers, 
      thereby resulting in severe neural, oxidative and lipoperoxidative damages in 
      MDMA abusers.
FAU - Zhou, Jun-Fu
AU  - Zhou JF
AD  - Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang 
      Surveillance Station of Drug Abuse, 88 Jiefang Road, Hangzhou 310009, Zhejiang 
      Province, China. zhuojun88@sina.com
FAU - Zhou, Ye-Hua
AU  - Zhou YH
FAU - Zhang, Liang
AU  - Zhang L
FAU - Chen, Huai-Hong
AU  - Chen HH
FAU - Cai, Dong
AU  - Cai D
LA  - eng
PT  - Journal Article
PL  - China
TA  - Biomed Environ Sci
JT  - Biomedical and environmental sciences : BES
JID - 8909524
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Lipid Peroxides)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Acetylcholinesterase/*metabolism
MH  - Adolescent
MH  - Adult
MH  - *Amphetamine-Related Disorders/blood/enzymology/metabolism
MH  - Catalase/blood
MH  - Cholinesterase Inhibitors/*adverse effects/urine
MH  - Erythrocytes/enzymology
MH  - Female
MH  - Humans
MH  - Lipid Peroxidation/*drug effects
MH  - Lipid Peroxides/blood
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects/urine
MH  - Oxidative Stress/*drug effects
MH  - Superoxide Dismutase/blood
EDAT- 2003/05/16 05:00
MHDA- 2003/08/05 05:00
CRDT- 2003/05/16 05:00
PHST- 2003/05/16 05:00 [pubmed]
PHST- 2003/08/05 05:00 [medline]
PHST- 2003/05/16 05:00 [entrez]
PST - ppublish
SO  - Biomed Environ Sci. 2003 Mar;16(1):53-61.