PMID- 12748489
OWN - NLM
STAT- MEDLINE
DCOM- 20030619
LR  - 20190616
IS  - 0002-9378 (Print)
IS  - 0002-9378 (Linking)
VI  - 188
IP  - 5
DP  - 2003 May
TI  - Interleukin-18 in the plasma of women with preeclampsia.
PG  - 1234-7
AB  - OBJECTIVE: Interleukin-18 (IL-18) is a proinflammatory cytokine capable of 
      stimulating interferon gamma and tumor necrosis factor-alpha production. Our 
      purpose was to determine whether abnormal levels of IL-18 in maternal plasma 
      correlate with the diagnosis of preeclampsia. STUDY DESIGN: A case control study 
      design was used to enroll 61 patients: controls (n = 31) and preeclamptic women 
      (n = 30). A standard enzyme-linked immunosorbent assay measured plasma IL-18. 
      Statistical methods included Student t tests and chi(2) tests. RESULTS: Mean 
      IL-18 levels were lower in preeclampsia than in controls (185 +/- 74 pg/mL vs 224 
      +/- 75 pg/mL, P =.053). Administration of betamethasone (BMZ) and/or hydralazine 
      (HYD) was significantly associated with a lower IL-18 compared with controls (159 
      +/- 50 pg/mL vs 224 +/- 75 pg/mL, P =.002). After women who received BMZ or HYD 
      were excluded, levels of IL-18 in preeclampsia were similar to those of controls 
      (213 +/- 87 pg/mL, P =.69). There was no association between gestational age and 
      IL-18. CONCLUSION: Lower IL-18 was associated with administration of either BMZ 
      or HYD. After patients receiving these medications were excluded, IL-18 levels 
      were similar in controls and preeclamptic women. IL-18 was not associated with 
      gestational age.
FAU - Adams, Kristina M
AU  - Adams KM
AD  - Department of Obstetrics and Gynecology and Fred Hutchinson Cancer Research 
      Center, University of Washington School of Medicine, Seattle, WA 98195, USA.
FAU - Mandel, Lynn S
AU  - Mandel LS
FAU - Guthrie, Katherine A
AU  - Guthrie KA
FAU - Atkinson, M Wendy
AU  - Atkinson MW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Glucocorticoids)
RN  - 0 (Interleukin-18)
RN  - 26NAK24LS8 (Hydralazine)
RN  - 9842X06Q6M (Betamethasone)
SB  - IM
MH  - Adult
MH  - Antihypertensive Agents/therapeutic use
MH  - Betamethasone/therapeutic use
MH  - Case-Control Studies
MH  - Drug Therapy, Combination
MH  - Female
MH  - Gestational Age
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Hydralazine/therapeutic use
MH  - Interleukin-18/*blood
MH  - Pre-Eclampsia/*blood/drug therapy
MH  - Pregnancy
EDAT- 2003/05/16 05:00
MHDA- 2003/06/20 05:00
CRDT- 2003/05/16 05:00
PHST- 2003/05/16 05:00 [pubmed]
PHST- 2003/06/20 05:00 [medline]
PHST- 2003/05/16 05:00 [entrez]
AID - S0002937803002618 [pii]
AID - 10.1067/mob.2003.349 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2003 May;188(5):1234-7. doi: 10.1067/mob.2003.349.