PMID- 12748676
OWN - NLM
STAT- MEDLINE
DCOM- 20040122
LR  - 20041117
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 31
IP  - 10
DP  - 2003 May
TI  - Concurrent presence of both patient and donor t(14;18) in a follicular lymphoma 
      patient after undergoing allogeneic BMT: implications for minimal residual 
      disease detection post-transplant.
PG  - 947-9
AB  - We report the case of a t(14:18)(+) follicular lymphoma (FL) patient in long-term 
      clinical remission after undergoing an allogeneic bone marrow transplantation 
      (allo-BMT) from a human leukocyte antigen (HLA)-identical sibling donor who was 
      the normal healthy carrier of a t(14:18)(+) B cell clone. Using real-time 
      quantitative PCR (RQ-PCR) and gel electrophoresis, we document the temporal 
      disappearance of the patient's t(14:18)(+) clone early post-transplant with the 
      concomitant emergence and long-term persistence of the donor's t(14:18)(+) clone 
      in the patient's peripheral blood. This report indicates that the use of 
      PCR-based techniques to measure minimal residual disease in FL patients 
      post-alloBMT should incorporate pretransplant screening of the donor for 
      t(14;18). Furthermore, it suggests that healthy individuals with t(14:18) need 
      not be excluded as donors for FL patients treated with allo-BMT.
FAU - Rosenblum, M D
AU  - Rosenblum MD
AD  - Department of Medical Scientist Training Program (MSTP), Medical College of 
      Wisconsin, Milwaukee, WI 53226, USA.
FAU - Drobyski, W R
AU  - Drobyski WR
FAU - Keever-Taylor, C
AU  - Keever-Taylor C
FAU - Chang, C-C
AU  - Chang CC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Adult
MH  - *Bone Marrow Transplantation
MH  - *Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 18
MH  - Female
MH  - Humans
MH  - *Living Donors
MH  - Lymphoma, Follicular/*genetics/*surgery
MH  - Neoplasm, Residual/*diagnosis
MH  - Polymerase Chain Reaction
MH  - *Translocation, Genetic
EDAT- 2003/05/16 05:00
MHDA- 2004/01/24 05:00
CRDT- 2003/05/16 05:00
PHST- 2003/05/16 05:00 [pubmed]
PHST- 2004/01/24 05:00 [medline]
PHST- 2003/05/16 05:00 [entrez]
AID - 1704039 [pii]
AID - 10.1038/sj.bmt.1704039 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2003 May;31(10):947-9. doi: 10.1038/sj.bmt.1704039.