PMID- 12748802
OWN - NLM
STAT- MEDLINE
DCOM- 20031209
LR  - 20061115
IS  - 0941-293X (Print)
IS  - 0941-293X (Linking)
VI  - 100
IP  - 5
DP  - 2003 May
TI  - [Angioproliferative retinal disease caused by ischemia].
PG  - 371-7
AB  - Ischemia is a major stimulus for angiogenesis, a biological response mechanism 
      that describes the formation of new blood vessels from existing vessels. An 
      ischemic cell communicates with endothelial cells by soluble factors such as VEGF 
      (vascular endothelial growth factor) and its receptors. A major transcriptional 
      factor for VEGF is HIF-1 (hypoxia inducible factor). Proliferation of endothelial 
      cells alone does not result in stable vascular tubes, this is only achieved by 
      recruiting additional cells such as pericytes. The stabilisation and 
      destabilisation of vessels, which are important prerequisites for vascular 
      growth, are in a dynamic equilibrium which can be modified by additional growth 
      factors such as angiopoietins. In this review we discuss some of the molecular 
      mechanisms leading from ischemia to proliferative retinopathy with a special 
      focus on retinopathy of prematurity and the closely related mouse model of 
      hyperoxia-induced retinopathy. This model is very useful when developing new 
      antiangiogenic therapies based on the increasing understanding of the molecular 
      pathogenesis of ischemic proliferative retinopathy.
FAU - Agostini, H T
AU  - Agostini HT
AD  - Universitats-Augenklinik Freiburg. agostini@aug.ukl.uni-freiburg.de
FAU - Hansen, L L
AU  - Hansen LL
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Angioproliferative Netzhauterkrankungen bei Ischamie.
PL  - Germany
TA  - Ophthalmologe
JT  - Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
JID - 9206148
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Humans
MH  - Infant, Newborn
MH  - Ischemia/pathology/*physiopathology
MH  - Mice
MH  - Retinal Neovascularization/pathology/*physiopathology
MH  - Retinal Vessels/pathology/*physiopathology
MH  - Retinopathy of Prematurity/pathology/physiopathology
MH  - Vascular Endothelial Growth Factor A/physiology
RF  - 37
EDAT- 2003/05/16 05:00
MHDA- 2003/12/10 05:00
CRDT- 2003/05/16 05:00
PHST- 2003/05/16 05:00 [pubmed]
PHST- 2003/12/10 05:00 [medline]
PHST- 2003/05/16 05:00 [entrez]
AID - 10.1007/s00347-003-0801-7 [doi]
PST - ppublish
SO  - Ophthalmologe. 2003 May;100(5):371-7. doi: 10.1007/s00347-003-0801-7.