PMID- 12749805
OWN - NLM
STAT- MEDLINE
DCOM- 20030926
LR  - 20190916
IS  - 0300-2896 (Print)
IS  - 0300-2896 (Linking)
VI  - 39
IP  - 5
DP  - 2003 May
TI  - [Asthmatic characteristics in smokers with advanced emphysema].
PG  - 221-5
AB  - OBJECTIVES: Most pneumologists assume that chronic asthma and emphysema 
      associated with smoking differ both in their etiology and type of inflammation. 
      However, it is difficult to study subjects who have both diseases simultaneously. 
      We designed a prospective study to determine whether or not some advanced 
      emphysema patients who are smokers have an asthmatic profile suggesting the two 
      diseases overlap. PATIENTS AND METHOD: Twenty-three smokers with moderate to 
      severe obstruction and radiologic signs of advanced emphysema were studied. The 
      following signs of asthma were analyzed for all patients: positive acute response 
      to bronchodilators, eosinophilia in peripheral blood, significant eosinophilia in 
      sputum, significant total serum immunoglobulin E (IgE) and specific IgE positive 
      for common allergens and fungi. An asthmatic profile was defined as the presence 
      of 3 or more of the aforementioned signs. Statistical analysis was by calculation 
      of the confidence interval on the total number of positive cases to estimate the 
      population percentage. RESULTS: Data on at least 4 characteristics were available 
      for 21 of the 23 patients. Ten (48%) of the 21 had asthmatic profiles (3 or more 
      of the aforementioned characteristics). This finding suggests that asthmatic 
      characteristics are present in between 17.6 and 79.6% of the studied population 
      with advanced emphysema, with a confidence interval of 99.9%. CONCLUSIONS: We 
      conclude that emphysema initially associated with smoking may mean that at least 
      17.6% of patients have a clear asthmatic profile, which indicates a high degree 
      of overlap between asthma and emphysema in smokers. Thus, our findings are 
      consistent with the Dutch theory that chronic obstructive diseases have a common 
      origin in underlying allergic sensitization and bronchial hyperresponsiveness 
      alongside various other influential factors such as tobacco smoking over the 
      course of disease.
FAU - Pacheco, A
AU  - Pacheco A
AD  - Servicio de Neumologia. Hospital Ramon y Cajal. Universidad de Alcala. Madrid. 
      Espana.
FAU - Maiz, L
AU  - Maiz L
FAU - Gaudo, J
AU  - Gaudo J
FAU - Pavon, M J
AU  - Pavon MJ
FAU - Cuevas, M
AU  - Cuevas M
FAU - Quirce, S
AU  - Quirce S
LA  - spa
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Caracteristicas asmaticas en pacientes fumadores con enfisema avanzado.
PL  - Spain
TA  - Arch Bronconeumol
JT  - Archivos de bronconeumologia
JID - 0354720
RN  - 0 (Bronchodilator Agents)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Administration, Inhalation
MH  - Aged
MH  - Aged, 80 and over
MH  - Asthma/*diagnosis/drug therapy/etiology
MH  - Bronchodilator Agents/therapeutic use
MH  - Diagnosis, Differential
MH  - Eosinophilia/blood/etiology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Pulmonary Emphysema/*diagnosis/drug therapy/etiology
MH  - Respiratory Function Tests
MH  - Smoking/*adverse effects
EDAT- 2003/05/17 05:00
MHDA- 2003/09/27 05:00
CRDT- 2003/05/17 05:00
PHST- 2003/05/17 05:00 [pubmed]
PHST- 2003/09/27 05:00 [medline]
PHST- 2003/05/17 05:00 [entrez]
AID - 13047336 [pii]
AID - 10.1016/s0300-2896(03)75365-4 [doi]
PST - ppublish
SO  - Arch Bronconeumol. 2003 May;39(5):221-5. doi: 10.1016/s0300-2896(03)75365-4.