PMID- 12750159
OWN - NLM
STAT- MEDLINE
DCOM- 20031029
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 102
IP  - 7
DP  - 2003 Oct 1
TI  - ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell 
      lymphoma.
PG  - 2638-41
AB  - We present 3 cases of large B-cell lymphoma (LBCL) with a granular cytoplasmic 
      staining for anaplastic lymphoma kinase (ALK). All of the cases showed striking 
      similarities in morphology and immunohistochemical profile characterized by a 
      massive monomorphic proliferation of CD20-/CD138+ plasmablast-like cells. In one 
      of the cases, initially diagnosed as a null-type anaplastic large cell lymphoma 
      (ALCL), the B-cell phenotype became evident only at recurrence. Fluorescent in 
      situ hybridization (FISH) and molecular studies led to the detection of a 
      CLTC-ALK rearrangement in all 3 cases, without any evidence of full-length ALK 
      receptor expression. The associated t(2;17)(p23;q23) was demonstrated in the 
      karyotype of 2 cases. Although a similar CLTC-ALK aberration was previously 
      identified in ALK-positive T-/null cell ALCL and inflammatory myofibroblastic 
      tumor, its association with ALK-positive LBCL seems to be specific and 
      intriguing.
FAU - De Paepe, Pascale
AU  - De Paepe P
AD  - Department of Pathology, Center of Medical Genetics and Pediatric Oncology, Ghent 
      University Hospital, Belgium.
FAU - Baens, Mathijs
AU  - Baens M
FAU - van Krieken, Han
AU  - van Krieken H
FAU - Verhasselt, Bruno
AU  - Verhasselt B
FAU - Stul, Michel
AU  - Stul M
FAU - Simons, Annet
AU  - Simons A
FAU - Poppe, Bruce
AU  - Poppe B
FAU - Laureys, Genevieve
AU  - Laureys G
FAU - Brons, Paul
AU  - Brons P
FAU - Vandenberghe, Peter
AU  - Vandenberghe P
FAU - Speleman, Frank
AU  - Speleman F
FAU - Praet, Marleen
AU  - Praet M
FAU - De Wolf-Peeters, Chris
AU  - De Wolf-Peeters C
FAU - Marynen, Peter
AU  - Marynen P
FAU - Wlodarska, Iwona
AU  - Wlodarska I
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20030515
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Clathrin)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (oncoprotein CLTCL-ALK)
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amino Acid Sequence
MH  - Anaplastic Lymphoma Kinase
MH  - Base Sequence
MH  - Child
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 2
MH  - Clathrin/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Lymphoma, B-Cell/*genetics/*metabolism
MH  - Male
MH  - Molecular Sequence Data
MH  - Oncogene Proteins, Fusion/genetics/*metabolism
MH  - Phenotype
MH  - Protein-Tyrosine Kinases/genetics/*metabolism
MH  - Receptor Protein-Tyrosine Kinases
EDAT- 2003/05/17 05:00
MHDA- 2003/10/30 05:00
CRDT- 2003/05/17 05:00
PHST- 2003/05/17 05:00 [pubmed]
PHST- 2003/10/30 05:00 [medline]
PHST- 2003/05/17 05:00 [entrez]
AID - S0006-4971(20)44098-4 [pii]
AID - 10.1182/blood-2003-04-1050 [doi]
PST - ppublish
SO  - Blood. 2003 Oct 1;102(7):2638-41. doi: 10.1182/blood-2003-04-1050. Epub 2003 May 
      15.