PMID- 12752335
OWN - NLM
STAT- MEDLINE
DCOM- 20031110
LR  - 20220408
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 58
IP  - 5
DP  - 2003 May
TI  - Specific sensitization to the common housefly (Musca domestica) not related to 
      insect panallergy.
PG  - 448-51
AB  - BACKGROUND: Allergy to houseflies is rare. We report a case of respiratory 
      allergy from occupational exposure to houseflies in a farmer. CASE REPORT: A 30 
      year-old female farmer with a long-standing history of grass pollen allergy 
      observed for 2 years rhino-conjunctivitis and mild asthma when entering livestock 
      stables and barns. Allergy retesting revealed sensitization to various pollens 
      but not to animal danders. Houseflies (Musca domestica) occurring on the farm in 
      great quantity were suspected by the farmer herself as the causative agent. 
      RESULTS: Skin prick testing with housefly was positive in the patient and 
      negative in four controls. Experimental radioallergosorbant test was class 3 
      positive. Sensitization to house dust mite, storage mites and cockroach was not 
      detectable. Western blots with housefly extracts revealed immunoglobulin E 
      (IgE)-binding to bands of 70, 50, and approximately 16 kDa. Tropomyosin in the 
      housefly extract (35 kDa) was recognized by a tropomyosin reference serum but not 
      by the patient. In enzyme-linked immunosorbent assay (ELISA) inhibition assays 
      using housefly as the solid phase, IgE-binding of the patient was inhibited by 
      75% by M. domestica and by 44% by the closely related lesser housefly (Fannia 
      canicularis), but not by extracts from blowfly (Lucilia spp.), fruit fly 
      (Drosophila spp.), horsefly (Haematopota pluvialis) and mosquito (Culex pipiens). 
      The IgE-binding of the tropomyosin control serum was inhibited by 60-80% by all 
      species. CONCLUSIONS: In accordance with previous reports, this case demonstrates 
      that respiratory sensitization to insects may be highly specific. According to 
      ELISA inhibition, cross-sensitization in the present case was restricted to 
      species of the family of true flies (Muscidae).
FAU - Focke, M
AU  - Focke M
AD  - Floridsdorf Allergy Centre, Vienna, Austria.
FAU - Hemmer, W
AU  - Hemmer W
FAU - Wohrl, S
AU  - Wohrl S
FAU - Gotz, M
AU  - Gotz M
FAU - Jarisch, R
AU  - Jarisch R
FAU - Kofler, H
AU  - Kofler H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
SB  - IM
CIN - Allergy. 2003 Sep;58(9):868-70. PMID: 12911414
MH  - Adult
MH  - Animals
MH  - Female
MH  - *Houseflies
MH  - Humans
MH  - Occupational Diseases/*etiology
MH  - Occupational Exposure/*adverse effects
MH  - Respiratory Hypersensitivity/*etiology
EDAT- 2003/05/20 05:00
MHDA- 2003/11/11 05:00
CRDT- 2003/05/20 05:00
PHST- 2003/05/20 05:00 [pubmed]
PHST- 2003/11/11 05:00 [medline]
PHST- 2003/05/20 05:00 [entrez]
AID - 126 [pii]
AID - 10.1034/j.1398-9995.2003.00126.x [doi]
PST - ppublish
SO  - Allergy. 2003 May;58(5):448-51. doi: 10.1034/j.1398-9995.2003.00126.x.