PMID- 12753507
OWN - NLM
STAT- MEDLINE
DCOM- 20030606
LR  - 20190818
IS  - 0300-9475 (Print)
IS  - 0300-9475 (Linking)
VI  - 57
IP  - 5
DP  - 2003 May
TI  - Increased brain-derived neurotrophic factor expression in white blood cells of 
      relapsing-remitting multiple sclerosis patients.
PG  - 493-7
AB  - Central nervous system (CNS)-autoreactive immune responses can exert 
      neuroprotective effects, possibly mediated via the release of neurotrophic 
      factors from infiltrating leucocytes. Herein, we analysed neurotrophin and 
      cytokine mRNA levels using TaqMan polymerase chain reaction in unstimulated 
      peripheral blood mononuclear cells (PBMCs) from multiple sclerosis (MS) patients 
      in remission and controls. We demonstrate that mRNA for brain-derived 
      neurotrophic factor (BDNF), but not neurotrophin-3 or nerve growth factor (NGF), 
      is readily detectable in PBMC and that levels in MS are increased by 
      approximately 60% compared with patients with other neurological diseases or 
      healthy subjects. These results provide additional evidence that a potentially 
      neuroprotective facet of autoimmune inflammation is present in MS.
FAU - Gielen, A
AU  - Gielen A
AD  - Department of Medicine, Karolinska Institute, Karolinska Hospital, Stockholm, 
      Sweden. sander.gielen@cmm.ki.se
FAU - Khademi, M
AU  - Khademi M
FAU - Muhallab, S
AU  - Muhallab S
FAU - Olsson, T
AU  - Olsson T
FAU - Piehl, F
AU  - Piehl F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Autoimmune Diseases/*blood/immunology
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*blood/genetics/physiology
MH  - Female
MH  - Humans
MH  - Interleukin-10/blood/genetics
MH  - Leukocytes/classification/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*blood/immunology
MH  - Nerve Growth Factor/blood/genetics
MH  - Nervous System Diseases/blood/immunology
MH  - Neurotrophin 3/blood
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/*blood
MH  - Tumor Necrosis Factor-alpha/analysis/genetics
EDAT- 2003/05/20 05:00
MHDA- 2003/06/07 05:00
CRDT- 2003/05/20 05:00
PHST- 2003/05/20 05:00 [pubmed]
PHST- 2003/06/07 05:00 [medline]
PHST- 2003/05/20 05:00 [entrez]
AID - 1260 [pii]
AID - 10.1046/j.1365-3083.2003.01260.x [doi]
PST - ppublish
SO  - Scand J Immunol. 2003 May;57(5):493-7. doi: 10.1046/j.1365-3083.2003.01260.x.